Factors influencing the composition of the weight lost by obese patients on a reducing diet
Factors influencing the composition of the weight lost by obese patients on a reducing diet
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肥胖患者减重减肥的影响因素
DOI：
10.1079/bjn19800042
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发表时间：
1980
影响因子：
3.6
通讯作者：
Penelope M. Warwick
中科院分区：
文献类型：
--
作者：
M. Durrant;John Garrow;P. Royston;Stalley Sf;S. Sunkin;Penelope M. Warwick
1.对40例肥胖住院患者进行减肥饮食治疗，测定其体重减轻、静息代谢率和氮丢失量。2. 5名受试者每天摄入3.55 MJ，持续6周（实验I）。21名受试者第1周摄入4.2MJ/d，第2周摄入2.0MJ/d，第3周摄入4.2MJ/d（实验2）。14名受试者在第一周摄入3.4 MJ/d，然后在第二周或第三周摄入0.87 MJ蛋白质或碳水化合物，使用交替患者的交叉设计（实验3）。3.实验I中的患者在前2周具有最高的体重减轻和N减少，但在剩余的几周内适应能量限制。平均而言，受试者在研究结束时处于N平衡状态。4.在实验2中，与第I周相比，第2周进食2.0 MJ/d的患者显示体重减轻增加。N损失没有增加，但没有像实验I中那样减少。体重减轻和氮损失在第三周恢复至4.2 MJ/d时减少。5.在实验3中，摄入0.87 MJ蛋白质的患者比摄入0.87 MJ碳水化合物的患者体重减轻明显更多，氮损失更少。6.低能量饮食下，静息代谢率随时间推移而下降，但能量或蛋白质含量的操纵并没有显着影响下降的模式。7.能量摄入越低，体重损失和氮损失越大，且两者均随时间而降低。具有高蛋白质：能量值的饮食在每个能量摄入水平下对N：体重减轻提供了有利的值。
1.Weight loss, resting metabolic rate and nitrogen loss were measured in forty obese inpatients on reducing diets. 2. Five subjects ate 3·55 MJ/d for 6 weeks (Expt I). Twenty-one subjects ate 4.2 MJ/d for the first week, 2·0 MJ/d for the second week and 4 2 MJ/d for the third week (Expt 2). Fourteen subjects ate 3·4 MJ/d for the first week and then 0.87 MJ protein or carbohydrate for the second or third weeks, using a cross-over design for alternate patients (Expt 3). 3. Patients in Expt I had highest weight loss and N loss in the first 2 weeks, but adapted to the energy restriction over the remaining weeks. On average subjects were in N balance at the end of the study. 4. In Expt 2 patients eating 2·0 MJ/d in week 2 showed increased weight loss compared with week I.N loss was not raised but it failed to decrease as it had in Expt I. Weight loss and N loss were reduced on return to 4.2 MJ/d for a third week. 5. In Expt 3 patients eating 0·87 MJ protein showed significantly more weight loss and less N loss than patients eating 0·87 MJ carbohydrate. 6. Resting metabolic rate decreased with time on the low-energy diet, but the manipulations of energy or protein content did not significantly affect the pattern of decrease. 7. Both weight loss and N loss were greater the lower the energy intake, and both decreased with time. Diets with a high protein:energy value give a favourable value for N:weight loss at each level of energy intake.