Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders.
Association of low-activity MAOA allelic variants with violent crime in incarcerated offenders.
复制标题
低活性 MAOA 等位基因变异与被监禁罪犯暴力犯罪的关联。
DOI：
10.1016/j.jpsychires.2014.07.006
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发表时间：
2014
影响因子：
4.8
通讯作者：
Bortolato,Marco
中科院分区：
文献类型：
--
作者：
Stetler,DeanA;Davis,Chad;Leavitt,Kathryn;Schriger,Ilana;Benson,Katie;Bhakta,Samir;Wang,LamChee;Oben,Cynthia;Watters,Matthew;Haghnegahdar,Tara;Bortolato,Marco
5-羟色胺降解的主要酶，单胺氧化酶（MAO）A，最近已经成为冲动性攻击倾向的关键生物因素。MAOA基因主要功能多态性的低活性变体（MAOA-uVNTR）的男性携带者表现出更大的暴力行为倾向。因此，我们假设低活性MAOA-uVNTR等位基因可能与男性罪犯中较高的犯罪暴力风险相关。为了验证这种可能性，我们分析了在一个教养所中的暴力（n= 49）和非暴力（n= 40）男性白人和非洲裔美国人罪犯的MAOA-uVNTR变体。所有参与者还接受了儿童期创伤问卷（CTQ），Barratt冲动量表（BIS-11）和Buss-Perry攻击问卷（BPAQ）的测试，以评估他们的儿童期创伤暴露，冲动和攻击水平。我们的研究结果揭示了低活性MAOA-uVNTR等位基因与暴力犯罪之间的强关联（P< 0.0001）。这种关联在白人暴力犯罪者组中得到复制（P< 0.01），但在非裔美国人中仅达到边缘趋势（P= 0.08）。虽然暴力犯罪指控与CTQ、BIS-11和BPAQ评分无关，但低活动等位基因携带者的BIS-11总分和注意力冲动评分轻度但显著（P< 0.05）增加。总之，这些发现支持了MAOA基因作为犯罪暴力的一个突出遗传决定因素的作用。需要进一步的研究，以确认这些结果在更大的样本的囚犯和评估潜在的相互作用之间的MAOA等位基因和环境脆弱性因素。
The main enzyme for serotonin degradation, monoamine oxidase (MAO) A, has recently emerged as a key biological factor in the predisposition to impulsive aggression. Male carriers of low-activity variants of the main functional polymorphism of theMAOAgene (MAOA-uVNTR) have been shown to exhibit a greater proclivity to engage in violent acts. Thus, we hypothesized that low-activityMAOA-uVNTRalleles may be associated with a higher risk for criminal violence among male offenders. To test this possibility, we analyzed theMAOA-uVNTRvariants of violent (n= 49) and non-violent (n= 40) male Caucasian and African-American convicts in a correctional facility. All participants were also tested with the Childhood Trauma Questionnaire (CTQ), Barratt Impulsivity Scale (BIS-11) and Buss-Perry Aggression Questionnaire (BPAQ) to assess their levels of childhood trauma exposure, impulsivity and aggression, respectively. Our results revealed a robust (P< 0.0001) association between low-activityMAOA-uVNTRalleles and violent crime. This association was replicated in the group of Caucasian violent offenders (P< 0.01), but reached only a marginal trend (P= 0.08) in their African American counterparts. While violent crime charges were not associated with CTQ, BIS-11 and BPAQ scores, carriers of low-activity alleles exhibited a mild, yet significant (P< 0.05) increase in BIS-11 total and attentional-impulsiveness scores. In summary, these findings support the role ofMAOAgene as a prominent genetic determinant for criminal violence. Further studies are required to confirm these results in larger samples of inmates and evaluate potential interactions betweenMAOAalleles and environmental vulnerability factors.