Kinesin-like proteins in the flagella of Chlamydomonas
Kinesin-like proteins in the flagella of Chlamydomonas
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DOI：
10.1016/0962-8924(94)90115-5
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发表时间：
1994-01-01
影响因子：
19
通讯作者：
Rosenbaum, Joel L.
中科院分区：
文献类型：
--
作者：
Bernstein, Mitchell;Rosenbaum, Joel L.
双鞭毛单细胞衣原体的鞭毛长期以来一直被认为含有微管依赖的运动蛋白动力蛋白，但最近的研究结果表明，它们也含有驱动蛋白超家族的多个成员。其中两个驱动蛋白样蛋白被限制在一个单一的中心对微管，提出了蛋白质如何靶向鞭毛内的特定微管的问题。在鞭毛跳动过程中，中心对微管上的驱动蛋白样蛋白可能导致中心对装置旋转或扭曲。鞭毛内的其他驱动蛋白可能参与与鞭毛膜相关的运动。
The flagella of the biflagellate unicellular alga Chlamydomonas have long been known to contain the microtubule-dependent motor protein dynein, but recent findings indicate they also contain multiple members of the kinesin superfamily. Two of these kinesin-like proteins are restricted to a single central-pair microtubule, raising the question of how proteins are targeted to specific microtubules within the flagellum. The kinesin-like proteins on the central-pair microtubules may cause the central-pair apparatus to rotate or twist during flagellar beating. Other kinesins within the flagellum may participate in movements associated with the flagellar membrane.