Pituitary adenylate cyclase-activating polypeptide hormone (PACAP) at very low dosages improves memory in the rat
Pituitary adenylate cyclase-activating polypeptide hormone (PACAP) at very low dosages improves memory in the rat
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DOI：
10.1006/nlme.2001.4014
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发表时间：
2001-07-01
影响因子：
2.7
通讯作者：
Brunelli, M
中科院分区：
文献类型：
--
作者：
Sacchetti, B;Lorenzini, CA;Brunelli, M
为了确定极低剂量的垂体腺苷环化酶激活多肽(PACAP)是否影响哺乳动物的学习，在被动回避反应(PAR)范式获得试验后，立即将PACAP-38按递增剂量(0、0.02、0.2、2、20和200 ng/10毫升生理盐水)注入不同组大鼠的脑室。分别在48h和96h后通过保持试验测定记忆效果。在中等浓度的PACAP-38中，PAR的助记力有显着改善。在注射0.2 ng PACAP-38(更长的避暗潜伏期)后，观察到最大的效果。在随后的较高浓度下，2 ng的影响较小。更高的剂量没有任何效果。结论：PACAP-38即使在很低的剂量下也可以作为哺乳动物记忆过程的增强剂。积极作用遵循倒U型剂量-反应曲线。这一结果可能对某些神经病理疾病的治疗有一定的指导意义。(C)2001年学术出版社。
To ascertain whether very low dosages of pituitary adenylate cyclase-activating polypeptide (PACAP) influence learning in mammals, immediately after the acquisition trial of a passive avoidance response (PAR) paradigm, PACAP-38 was administered intracerebroventricularly at increasing dosages (0, 0.02, 0.2, 2, 20, and 200 ng in 10 mul saline) to different groups of rats. The mnemonic effects were measured by means of retention testing 48 and 96 h later. At intermediate PACAP-38 concentrations there was a significant mnemonic improvement of the PAR. The maximal effect was observed after the 0.2-ng PACAP-38 administration (longer step-through latencies). There was a lesser effect at the subsequent higher concentration, 2 ng. Higher dosages had no effects. It is concluded that PACAP-38 acts as an enhancer of mammalian mnemonic processes even at very low dosages. The positive effect follows an inverted U-shaped dose-response curve. The results may be of interest for the therapy of some neuropathological conditions. (C) 2001 Academic Press.