Vitamin D Status and Tooth Loss in Postmenopausal Females: The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study.
Vitamin D Status and Tooth Loss in Postmenopausal Females: The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) Study.
复制标题
DOI：
10.1902/jop.2016.150733
复制
发表时间：
2016-08
影响因子：
4.3
通讯作者：
Millen AE
中科院分区：
文献类型：
--
作者：
Pavlesen S;Mai X;Wactawski-Wende J;LaMonte MJ;Hovey KM;Genco RJ;Millen AE
维生素D被假设通过其对骨骼健康，炎症和免疫反应的影响来降低牙齿脱落的风险。我们在一组绝经后妇女中研究了血浆25-羟基维生素D（25[OH]D）浓度与牙齿脱落的患病率和5年发病率之间的关系。参与者在研究基线（1997-2000）和随访（2002-2005）时接受口腔检查，以分别确定缺失牙齿的数量和5年牙齿缺失的发生率。在两次访问中，女性自我报告了每颗牙齿缺失的原因。在基线时，152名妇女报告没有牙齿脱落的历史，628名被归类为报告由于牙周病（n=70）或龋齿（n=558）（总n=780）牙齿脱落的历史。在随访时，96，376，48和328名妇女被归类为上述类别的事件牙齿脱落的原因（总n=472）。采用逻辑回归分析，根据基线25（OH）D（nmol/L）浓度的类别，估计牙齿脱落的比值比（OR）和95%置信区间（CI）。模型根据年龄、收入、吸烟状况、牙科就诊频率、腰围和娱乐性体育活动进行调整。使用25（OH）D的连续浓度估计趋势P。在25（OH）D ≥50的女性中（充足的维生素D状态）与<50 nmol/L相比（缺乏/不充分），调整后的OR（95% CI）为1.24 [0.82-1.87]，病史的p趋势=0.049牙周病或龋齿导致的牙齿缺失的发生率为1.07 [0.62-1.85]，p趋势=0.111。25（OH）D与牙周病引起的牙齿缺失的历史或发病率之间没有统计学显著相关性。随着25（OH）D浓度的增加，观察到因龋齿导致牙齿脱落的几率增加（p趋势=0.045），但在前瞻性分析中未得到证实。在这个绝经后妇女队列中，数据不支持维生素D状态和牙齿脱落之间的关联。
Vitamin D is hypothesized to reduce risk for tooth loss via its influence on bone health, inflammation, and the immune response. We examined the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and the prevalence and 5-year incidence of tooth loss in a cohort of postmenopausal women. Participants underwent oral examinations at study baseline (1997–2000) and follow-up (2002–2005) to determine the number of missing teeth and the 5-year incidence of tooth loss, respectively. At both visits women self-reported reasons for each missing tooth. At baseline, 152 women reported no history of tooth loss and 628 were categorized as reporting a history of tooth loss due to periodontal disease (n=70) or caries (n=558) (total n=780). At follow-up, 96, 376, 48, and 328 women were categorized into the aforementioned categories as reasons for incident tooth loss (total n=472). Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for tooth loss by category of baseline 25(OH)D (nmol/L) concentrations. Models were adjusted for age, income, smoking status, frequency of dental visits, waist circumference and recreational physical activity. P for trend was estimated using continuous concentrations of 25(OH)D. Among women with 25(OH)D ≥50 (adequate vitamin D status) compared to <50 nmol/L (deficient/inadequate), the adjusted ORs (95% CI) was 1.24 [0.82–1.87], p-trend=0.049 for the history (prevalence) of tooth loss due to periodontal disease or caries and 1.07 [0.62–1.85], p-trend=0.111 for the incidence of tooth loss due to periodontal disease or caries. No statistically significant association was observed between 25(OH)D and the history or incidence of tooth loss due to periodontal disease. An increased odds of the history of tooth loss due to caries was observed with increasing concentrations of 25(OH)D (p-trend=0.045), but was not confirmed in prospective analyses. In this cohort of postmenopausal women, the data do not support an association between vitamin D status and tooth loss.