Variations in CS associability and multiple unit hippocampal activity in the rabbit.
Variations in CS associability and multiple unit hippocampal activity in the rabbit.
复制标题
兔子 CS 关联性和多单位海马活动的变化。
DOI：
10.1016/s0166-4328(99)00031-5
复制
发表时间：
1999
影响因子：
2.7
通讯作者：
Romano,AG
中科院分区：
文献类型：
--
作者：
Romano,AG
海马多个单位的活动记录在兔子在每四个preacquisition治疗，并在随后的经典条件反射的瞬膜反应。采用三种预暴露条件：CS单独介绍，介绍了CS与第二，中性刺激配对，或不配对介绍的CS和第二刺激。据预测，（a）单独CS预暴露将产生海马活动的减少和随后的条件反应（CR）获取的延迟率和（B）这两种效应的幅度将被与第二刺激配对的CS预暴露减弱。结果部分支持这两种预测。海马神经元的活动受到抑制，在CS单独预暴露和抑制减弱配对的CS与第二个，中性刺激。从行为上看，与未预暴露的对照组相比，所有预暴露组均表现出同等的、延迟的习得率。海马活动在整个收购是显着更大的nonpreexposed组相比，组预先暴露于CS单独。其他两组的海马活性介于非预暴露组和单独CS组之间。这表明，海马活动的幅度的改变可能提供了一个可靠的，神经元相关的CS关联性的变化。
Hippocampal multiple unit activity was recorded in rabbits during each of four preacquisition treatments and during subsequent classical conditioning of the nictitating membrane response. Three preexposure conditions were employed: CS alone presentations, presentations of the CS paired with a second, neutral stimulus, or unpaired presentations of the CS and second stimulus. It was predicted that (a) CS alone preexposures would produce a decrease in hippocampal activity and a retarded rate of subsequent conditioned response (CR) acquisition and (b) the magnitude of both effects would be attenuated by preexposures of the CS paired with a second stimulus. The results partially supported both predictions. Hippocampal activity was inhibited during CS alone preexposures and that inhibition was attenuated by pairing the CS with a second, neutral stimulus. Behaviorally, all of the preexposure groups showed equivalent, retarded rates of acquisition compared to a nonpreexposed control group. Hippocampal activity throughout acquisition was significantly greater in the nonpreexposed group compared to the group preexposed to the CS alone. Hippocampal activity of the other two groups was intermediate between the nonpreexposed and the CS alone groups. It is suggested that alterations in the magnitude of hippocampal activity may provide a reliable, neuronal correlate of CS associability changes.