Re-emergence of chikungunya and o'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships
Re-emergence of chikungunya and o'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships
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DOI：
10.1099/0022-1317-81-2-471
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发表时间：
2000-02-01
影响因子：
3.8
通讯作者：
Weaver, SC
中科院分区：
文献类型：
--
作者：
Powers, AM;Brault, AC;Weaver, SC
基孔肯雅病毒（Chikungunya，CHIK）是披膜病毒科甲病毒属的成员，在血清学上，它与奥-尼永（o 'nyong-nyong，ONN）病毒最密切相关，并且是塞姆利基森林抗原复合物的成员。据信，CHIK病毒在非洲大部分地区流行，历史证据表明，它从这个起源传播到世界其他地区。据报道，来自非洲和亚洲的菌株在生物学上存在差异，这表明可能存在不同的谱系。为了使用遗传数据检查CHIK和ONN病毒的相关性，我们对在非洲和东南亚获得的分离株进行了系统发育研究。分析表明，ONN病毒确实与CHIK病毒不同，这些病毒可能在数千年前分化。两个不同的CHIK病毒谱系被划定，一个包含所有来自西非的分离株，第二个包括所有南部和东非毒株，以及来自亚洲的分离株。系统发育树证实了CHIK病毒起源于非洲，随后传入亚洲的历史证据。在东非和南部非洲/亚洲谱系内，亚洲菌株以不同于非洲群体的基因型聚集在一起。这些不同的地理基因型在其传播周期中表现出差异：在亚洲，该病毒似乎与埃及伊蚊蚊媒维持在城市周期中，而CHIK病毒在非洲的传播涉及森林周期，主要是Ae。furcifer和Ae.非洲蚊
Chikungunya (CHIK) virus is a member of the genus Alphavirus in the family Togaviridae, Serologically, it is most closely related to o'nyong-nyong (ONN) virus and is a member of the Semliki Forest antigenic complex. CHIK virus is believed to be enzootic throughout much of Africa and historical evidence indicates that it spread to other parts of the world from this origin. Strains from Africa and Asia are reported to differ biologically, indicating that distinct lineages may exist. To examine the relatedness of CHIK and ONN viruses using genetic data, we conducted phylogenetic studies on isolates obtained throughout Africa and Southeast Asia. Analyses revealed that ONN virus is indeed distinct from CHIK viruses, and these viruses probably diverged thousands of years ago. Two distinct CHIK virus lineages were delineated, one containing all isolates from western Africa and the second comprising all southern and East African strains, as well as isolates from Asia. Phylogenetic trees corroborated historical evidence that CHIK virus originated in Africa and subsequently was introduced into Asia. Within the eastern Africa and southern Africa/Asia lineage, Asian strains grouped together in a genotype distinct from the African groups. These different geographical genotypes exhibit differences in their transmission cycles: in Asia, the virus appears to be maintained in an urban cycle with Aedes aegypti mosquito vectors, while CHIK virus transmission in Africa involves a sylvatic cycle, primarily with Ae. furcifer and Ae. africanus mosquitoes.