Postsynaptic mechanisms of CO2 responses in parafacial pre-inspiratory neurons of newborn rats
Postsynaptic mechanisms of CO2 responses in parafacial pre-inspiratory neurons of newborn rats
复制标题
新生大鼠面旁前吸气神经元 CO2 反应的突触后机制
DOI：
10.1113/jphysiol.2011.222687
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Onimaru;H.;Ikeda;K.;Kawakami;K.
关键点·延髓中控制呼吸的中枢化学感受器改变CO2浓度并调节呼吸活动。·在延髓头端和腹外侧的面旁区表达转录因子Phox2b的神经元被高碳酸刺激兴奋，并被认为在中枢化学感受中发挥重要作用。在这项研究中，我们证明了新生大鼠中表达Phox2b的面旁神经元通过直接作用于突触后膜而对高碳酸血症敏感，而没有假定的突触前或其他钙依赖性成分的贡献。由于这些面旁神经元也是新生儿呼吸节律发生器的一部分，它们对出生后的生存至关重要，这可能是由于它们对中枢化学感受和呼吸节律产生的贡献。
Key points•The central chemoreceptors for respiratory control in the medulla sense changes in CO2concentration and regulate respiratory activity.•Neurons that express a transcription factor, Phox2b, in the parafacial region of the rostral and ventrolateral medulla are excited by hypercapnic stimulation and are proposed to play an important role in central chemoreception.•In this study, we show evidence that Phox2b‐expressing parafacial neurons in neonatal rats were sensitive to hypercapnia via direct action on the postsynaptic membrane without contribution of putative presynaptic or other calcium‐dependent components.•Since these parafacial neurons are also a part of the respiratory rhythm generator in neonates, they are essential for postnatal survival, which is probably due to their contribution to central chemoreception as well as respiratory rhythm generation.