Determinants of quality of life in chronic liver patients
Determinants of quality of life in chronic liver patients
复制标题
DOI：
10.1111/j.1365-2036.2006.02934.x
复制
发表时间：
2006-06-01
影响因子：
7.6
通讯作者：
Darlington, A. -S. E.
中科院分区：
文献类型：
--
作者：
Gutteling, J. . J. .;De Man, R. A.;Darlington, A. -S. E.
背景和目的许多研究表明慢性肝病患者的健康相关生活质量受损。然而，影响慢性肝病患者健康相关生活质量的因素尚不清楚。这是第一个研究，以评估身体和心理社会因素的影响，对加权评分的健康相关的生活质量在慢性肝病患者。方法1175例慢性肝病患者的数据被用来评估项目的疾病特异性肝病症状指数2.0和简表（SF）之间的关系。结果健康相关生活质量与疾病严重程度（B = -0.029）和关节疼痛（B = -0.023）的相关性最强。抑郁（B = -0.014）、右上腹疼痛（B = -0.014）、食欲减退（B = 0.014）和疲劳（B = -0.013）也与健康相关生活质量密切相关。在丙型肝炎病毒患者，疾病的严重程度（B = -0.037）和抑郁症（B = -0.030）的健康相关的生活quality of life.Conclusions这项研究表明，健康相关的生活质量在慢性肝病患者的疾病严重程度，关节疼痛，抑郁，食欲下降和疲劳明确决定。这些患者可能从旨在改善对所述症状的适应的干预措施中获益最多。
Background and aim Health-related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health-related quality of life in treated chronic liver patients are not quite known. This is the first study to assess the impact of physical and psychosocial determinants on a weighted score of health-related quality of life in patients with chronic liver disease.Methods The data of 1175 chronic liver patients were used to assess the relationship between items of the disease-specific Liver Disease Symptom Index 2.0 and the Short Form (SF)-6D weighted utility score by means of linear regression analyses.Results Health-related quality of life was most strongly related to disease severity (B = -0.029) and joint pain (B = -0.023). Depression (B = -0.014), pain in the right upper abdomen (B = -0.014), decreased appetite (B = 0.014) and fatigue (B = -0.013) were also strongly related to health-related quality of life. In hepatitis C virus patients, disease severity (B = -0.037) and depression (B = -0.030) were strong determinants of health-related quality of life.Conclusions This study shows that health-related quality of life in chronic liver patients is clearly determined by disease severity, joint pain, depression, decreased appetite and fatigue. These patients may benefit most from interventions aimed at improving adaptation to the symptoms described.