Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice.
Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice.
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DOI：
10.1016/0014-2999(93)90118-2
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发表时间：
1993-02
影响因子：
5
通讯作者：
A. Calignano;P. Persico;F. Mancuso;L. Sorrentino
中科院分区：
文献类型：
--
作者：
A. Calignano;P. Persico;F. Mancuso;L. Sorrentino
Opioids increase the dopaminergic turnover in nucleus striatum and nucleus accumbens of mice, causing behavioural changes such as increased locomotion and food intake. We have now shown that L-arginine administration increases morphine-induced locomotion and changes in food intake in mice. D-Arginine had no effect, suggesting a stereospecific mechanism. Furthermore NG-nitro-L-arginine methyl ester, a specific inhibitor of nitric oxide synthase, reduced the morphine-induced effects. These results suggest that endogenous nitric oxide could play a role in the modulation of dopaminergic effects elicited by morphine.
