Neurophysiological effects of vasotocin and corticosterone on medullary neurons: implications for hormonal control of amphibian courtship behavior.
Neurophysiological effects of vasotocin and corticosterone on medullary neurons: implications for hormonal control of amphibian courtship behavior.
复制标题
催产素和皮质酮对髓质神经元的神经生理学影响：对两栖动物求爱行为的激素控制的影响。
DOI：
10.1159/000127030
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发表时间：
1995
影响因子：
4.1
通讯作者：
Moore,FL
中科院分区：
文献类型：
--
作者：
Rose,JD;Kinnaird,JR;Moore,FL
对从鱼类到哺乳动物的各种脊椎动物的研究表明，皮质类固醇激素和血管生成素样神经肽可以有效地调节生殖行为。但是，目前尚不清楚这些化学信使的行为效应如何与行为控制神经元的功能特性相关。这个问题进行了调查，在糙皮蝾螈，Taricha颗粒，两栖动物，其中精氨酸催产素（AVT）的管理促进和皮质酮（CORT）抑制求爱的男性女性紧握。在清醒的，固定的雄性蝾螈，AVT和CORT的神经生理学效应进行了研究，由于这些神经元的控制可能的作用，在延髓吻端的神经元。局部髓质应用的一个clasp促进剂量的AVT产生了迅速增加的神经元反应的压力泄殖腔，扣反应的触发刺激。神经元对非泄殖腔躯体刺激和移动视觉刺激的反应也得到增强。系统CORT管理，这已被证明是抑制蝾螈髓神经元的感觉反应，逆转AVT的作用，使肽抑制感觉反应时，CORT后30分钟。然而，当AVT应用先于CORT注射10-17分钟时，通常的抑制性CORT效应被逆转，并且这种治疗导致迅速出现的神经元活性增强和增强的躯体感觉反应性。如果AVT和CORT之间的时间间隔增加到30分钟，类固醇会导致大多数神经元的快速放电抑制和躯体感觉反应减弱，类似于单独使用CORT治疗的蝾螈。这些结果表明，AVT或CORT的神经生理作用取决于先前的激素暴露的类型（用AVT或CORT预处理）和激素作用之间的时间间隔。
Research on a wide variety of vertebrates, from fish to mammals, reveals that corticosteroid hormones and vasotocin-like neuropeptides can potently modulate reproductive behaviors. But, it is not clear how the behavioral effects of these chemical messengers relate to functional properties of behavior-controlling neurons. This problem was investigated in the roughskin newt,Taricha granulosa, an amphibian in which the administration of arginine vasotocin (AVT) facilitates and corticosterone (CORT) inhibits courtship clasping of females by males. In waking, immobilized male newts, neurophysiological effects of AVT and CORT were studied in neurons in the rostral medulla due to the probable role of these neurons in the control of clasping. Topical medullary application of a clasp-facilitating dose of AVT produced a rapid increase in neuronal responsiveness to pressure on the cloaca, a trigger stimulus for clasping responses. Neuronal responses to noncloacal somatic stimuli and to moving visual stimuli were also enhanced. Systemic CORT administration, which has previously been shown to depress newt medullary neuronal sensory responsiveness, reversed the action of AVT such that the peptide depressed sensory responsiveness when applied 30 min after CORT. When AVT application prededed CORT injection by 10–17 min, however, the usual suppressive CORT effect was reversed and this treatment resulted in a rapidly appearing potentiation of neuronal activity and enhanced somatic sensory responsiveness. If the interval between AVT and CORT was increased to 30 min, the steroid caused a rapid depression of firing and a diminished somatic sensory responsiveness in most neurons, similar to what occurs in newts treated with CORT alone. These results indicate that neurophysiological actions of AVT or CORT depend on the type of prior hormonal exposure (pretreatment with AVT of CORT) and the time interval between hormone actions.