Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion.
Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion.
复制标题
色氨酸耗尽后 5-HTTLPR S 多态性携带者对恐惧面部表情的识别能力受损。
DOI：
10.1007/s00213-006-0581-2
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发表时间：
2006
影响因子：
3.4
通讯作者：
Blair,RJR
中科院分区：
文献类型：
--
作者：
Marsh,AbigailA;Finger,ElizabethC;Buzas,Beata;Soliman,Niveen;Richell,RebeccaA;Vythilingham,Meena;Pine,DanielS;Goldman,David;Blair,RJR
血清素转运体5 '启动子区域（5- httlpr）的rationalgenotype与调节急性色氨酸耗损对神经认知功能的影响有关。急性色氨酸消耗与处理恐惧相关线索（如情绪表达）有关，但5-HTTLPR基因型的影响尚未得到评估。目的探讨急性色氨酸耗损对健康志愿者（所有纯合子或5个携带者）标准化情绪面部表情识别的影响。材料和方法采用双盲组间设计，随机选择志愿者服用含有色氨酸的氨基酸混合物胶囊或含有乳糖的安慰剂胶囊。服用胶囊5小时后，受试者被要求识别愤怒、厌恶、恐惧、快乐、悲伤和惊讶的表情，这些表情以5%的步骤从中性到每一种完整的情绪表达。结果色氨酸缺失显著损害了5个携带者对恐惧面部表情的识别，而非所有纯合子。这种损伤是针对恐惧表情的。对其他表情的识别无显著差异。在5个携带者中，游离色氨酸水平与恐惧识别相关，但与所有纯合子无关。结论急性色氨酸缺失对5-HTTLPR情绪表达加工的影响随基因型的变化而变化。基因缺失会损害5个携带者对恐惧的识别，但不会损害所有纯合子的识别。这一发现强化了在评估药理学调节的行为效应时考虑基因型的重要性。
RationaleGenotype at the 5′ promoter region (5-HTTLPR) of the serotonin transporter has been implicated in moderating the effects of acute tryptophan depletion on neurocognitive functioning. Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed.ObjectiveThe present study investigated the effects of acute tryptophan depletion on the recognition of standardized facial expressions of emotions in healthy volunteers classified as ll homozygotes or s carriers.Materials and methodsA double-blind between-groups design was used with volunteers randomly selected to ingest capsules containing an amino acid mixture specifically lacking tryptophan, or placebo capsules containing lactose. 5 h after capsule ingestion, subjects were required to identify anger, disgust, fear, happiness, sadness, and surprise expressions that progressed from neutral to each full emotional expression in 5% steps.ResultsTryptophan depletion significantly impaired the recognition of fearful facial expressions in s carriers but not ll homozygotes. This impairment was specific to fear expressions. No significant differences in the recognition of other expressions were found. Free tryptophan levels were correlated with fear recognition in s carriers but not ll homozygotes.ConclusionsThe effects of acute tryptophan depletion on the processing of emotional expressions varies as a function of genotype at the 5-HTTLPR. Depletion impairs the recognition of fear in s carriers but not ll homozygotes. This finding reinforces the importance of considering genotype when assessing the behavioral effects of pharmacologic modulation.