An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster.
An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster.
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作者：
Gkanias E;McCurdy LY;Nitabach MN;Webb B
昆虫根据它们与积极或消极的强化物（如糖或冲击）的配对来调整它们对刺激（如气味）的反应。最近在果蝇的电生理和成像研究结果允许详细检查的神经机制，支持收购，遗忘和同化的记忆。我们建议，这个数据可以解释的组合多巴胺能可塑性规则，支持各种突触强度变化的现象，和电路结构（来自神经解剖学）之间的多巴胺能和输出神经元，创造不同的角色，为特定的神经元。计算模型表明，该电路允许快速的内存获取，从短期到长期的转移，以及探索/开发权衡。该模型可以再现观察到的变化，在活动中的每个识别的神经元的调节范例，并可用于灵活的行为控制。
Insects adapt their response to stimuli, such as odours, according to their pairing with positive or negative reinforcements, such as sugar or shock. Recent electrophysiological and imaging findings in Drosophila melanogaster allow detailed examination of the neural mechanisms supporting the acquisition, forgetting, and assimilation of memories. We propose that this data can be explained by the combination of a dopaminergic plasticity rule that supports a variety of synaptic strength change phenomena, and a circuit structure (derived from neuroanatomy) between dopaminergic and output neurons that creates different roles for specific neurons. Computational modelling shows that this circuit allows for rapid memory acquisition, transfer from short term to long term, and exploration/exploitation trade-off. The model can reproduce the observed changes in the activity of each of the identified neurons in conditioning paradigms and can be used for flexible behavioural control.