Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB x NZW) F1 mice
Early hyperbaric oxygen therapy attenuates disease severity in lupus-prone autoimmune (NZB x NZW) F1 mice
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DOI：
10.1016/s1521-6616(03)00091-3
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发表时间：
2003-08-01
影响因子：
8.6
通讯作者：
Sytwu, HK
中科院分区：
文献类型：
--
作者：
Chen, SY;Chen, YC;Sytwu, HK
据报道，高压氧（HBO2）治疗对免疫系统的影响，包括对CD4/CD8比率的潜在变化和暴露期间淋巴细胞增殖的降低。 HBO2的免疫抑制作用被认为适用于某些自身免疫性疾病的治疗。 （NZB X NZW）F1杂交小鼠是独特的狼疮小鼠，已用于阐明SLE的发病机理。为了研究HBO2对NZB/W F1狼疮小鼠的影响，将32只雌性小鼠分为四组。从（a）3个月，（b）6个月或（c）8个月大的HBO2（2.5 atm ABS（ATA）每天90分钟）用HBO2（2.5 atm ABS（ATA））处理三组小鼠，其余组（d）作为对照。遵循动物直到11个月大。实验参数包括寿命，蛋白尿。周围淋巴细胞，抗DSDNA抗体滴度和肾脏组织病理学。 HBO2治疗导致生存率增加，蛋白尿降低，淋巴细胞 - 固定重新分布的改变，抗DSDNA抗体滴度降低以及A组中免疫复合沉积的改善。我们的数据表明，HBO2治疗在NZB/W B/w疾病中疾病严重程度F1小鼠。 HBO2治疗可能用于狼疮患者的临床治疗，并将受益于进一步的研究。 （C）2003 Elsevier Science（美国）。所有的战斗都保留。
The effects of hyperbaric oxygen (HBO2) therapy on the immune system are reported including potential changes to the CD4/CD8 ratio and a decreased proliferation of lymphocytes during exposure. The immunosuppressive effect of HBO2 had been suggested to be applicable for the treatment of certain autoimmune diseases. (NZB x NZW) F1 hybrid mice, the unique lupus-prone mice, have been used for elucidating the pathogenesis of SLE. To investigate the effect of HBO2 on NZB/W F1 lupus-prone mice, 32 female mice were divided into four groups. Three groups of mice were treated with HBO2 (2.5 atm abs (ATA) for 90 min daily over 2 weeks) starting at (A) 3 months, (B) 6 months, or (C) 8 months of age, while the remaining group (D) served as control. Animals were followed until 11 months of age. Experimental parameters included life span, proteinuria. peripheral lymphocytes, anti-dsDNA antibody titers, and renal histopathology. HBO2 treatment resulted in increased survival, decreased proteinuria, alterations in lymphocyte-subset redistribution, reduced anti-dsDNA antibody titers, and amelioration of immune-complex deposition in groups A and B. Our data demonstrated that HBO2 therapy attenuated disease severity in NZB/W F1 mice. HBO2 treatment may be of use in the clinical treatment of lupus patients and would benefit from further study. (C) 2003 Elsevier Science (USA). All fights reserved.