Identification of the First Human Gyrovirus, a Virus Related to Chicken Anemia Virus
Identification of the First Human Gyrovirus, a Virus Related to Chicken Anemia Virus
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DOI：
10.1128/jvi.00639-11
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发表时间：
2011-08-01
影响因子：
5.4
通讯作者：
Eloit, Marc
中科院分区：
文献类型：
--
作者：
Sauvage, Virginie;Cheval, Justine;Eloit, Marc
我们在健康供体的皮肤拭子样本中发现了一种新病毒，我们将其命名为人类陀螺病毒（HGyV），因为它与鸡贫血病毒（CAV）相似，而CAV是以前唯一已知的陀螺病毒属成员。特别地，该病毒编码CAV抑制蛋白的同源物，CAV抑制蛋白是一种选择性诱导癌细胞凋亡的蛋白质。经PCR筛查，115例非病变皮肤标本中有5例检出HGyV，92例支气管肺泡灌洗液或鼻咽吸出物中无一例检出，92例粪便标本中无一例检出。
We have identified in a skin swab sample from a healthy donor a new virus that we have named human gyrovirus (HGyV) because of its similarity to the chicken anemia virus (CAV), the only previously known member of the Gyrovirus genus. In particular, this virus encodes a homolog of the CAV apoptin, a protein that selectively induces apoptosis in cancer cells. By PCR screening, HGyV was found in 5 of 115 other nonlesional skin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples.