Danish Breast Cancer Cooperative Group.
Danish Breast Cancer Cooperative Group.
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DOI：
10.2147/clep.s99457
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发表时间：
2016
影响因子：
3.9
通讯作者：
Mouridsen H
中科院分区：
文献类型：
--
作者：
Christiansen P;Ejlertsen B;Jensen MB;Mouridsen H
丹麦乳腺癌合作小组（DBCG）于1977年作为一个全国性的多学科小组成立，并建立了相关数据库，其最终目的是改善乳腺癌的预后。从那时起，该数据库记录了被诊断为原发性浸润性非转移性乳腺癌的妇女。从科室报告到数据库的数据包括原发肿瘤、手术、放疗和全身治疗的特征细节，以及有关科室具体形式的随访报告。从1977年到2014年，约11万名患者在全国临床数据库中登记。完成度逐步提高到95%以上。DBCG不断编制以证据为基础的乳腺癌诊断和治疗指南，并进行质量控制研究，以确定不同科室对指南的遵守程度。利用DBCG数据库的数据，一长串不同设计和范围的高质量DBCG研究，在全国或国际合作中，有助于当前指南的更新，并已成为改善丹麦乳腺癌管理和预后的重要资源。因此，自DBCG建立以来，乳腺癌的预后不断改善，5年死亡率从~37%下降到15%。
Danish Breast Cancer Cooperative Group (DBCG), with an associated database, was introduced as a nationwide multidisciplinary group in 1977 with the ultimate aim to improve the prognosis in breast cancer. Since then, the database has registered women diagnosed with primary invasive nonmetastatic breast cancer. The data reported from the departments to the database included details of the characteristics of the primary tumor, of surgery, radiotherapy, and systemic therapies, and of follow-up reported on specific forms from the departments in question. From 1977 through 2014, ~110,000 patients are registered in the nationwide, clinical database. The completeness has gradually improved to more than 95%. DBCG has continuously prepared evidence-based guidelines on diagnosis and treatment of breast cancer and conducted quality control studies to ascertain the degree of adherence to the guidelines in the different departments. Utilizing data from the DBCG database, a long array of high-quality DBCG studies of various designs and scope, nationwide or in international collaboration, have contributed to the current updating of the guidelines, and have been an instrumental resource in the improvement of management and prognosis of breast cancer in Denmark. Thus, since the establishment of DBCG, the prognosis in breast cancer has continuously improved with a decrease in 5-year mortality from ~37% to 15%.