CORTICOSTEROIDS AND THE BRAIN
CORTICOSTEROIDS AND THE BRAIN
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DOI：
10.1016/0960-0760(90)90489-8
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发表时间：
1990-11-20
影响因子：
4.1
通讯作者：
SUTANTO, W
中科院分区：
文献类型：
--
作者：
DEKLOET, ER;REUL, JMHM;SUTANTO, W
盐皮质激素（MR）和糖皮质激素受体（GR）在中枢神经系统中表达。放射性配体结合研究、放射自显影、免疫细胞化学和原位杂交表明，MR 和 GR 在边缘系统（海马）的神经元中大量存在，边缘系统是一种参与情绪、情感和下丘脑-垂体-肾上腺 (HPA) 轴微妙控制的结构。在海马体中，MR 以高亲和力结合皮质酮 (CORT) 和醛固酮 (ALDO)。面对其 2-3 个数量级的高循环浓度，MR 似乎主要被 CORT 占据。 GR 与 CORT 的亲和力低 6-10 倍。MR 和 GR 基因表达以及天然受体蛋白似乎以协调方式控制。当 GR 被过量的同源类固醇下调时，MR 似乎会增加。 MR 的下调也会降低 GR。 MR 和 GR 显示出差异的个体发生模式。当动物在产后第一周暴露于母体剥夺、处理、CORT 或 ACTH1-24 注射时，个体发育，特别是 GR 的个体发育，可能会受到永久性影响。这些 MR 和 GR 变化持续到衰老，并被认为会导致 CORT 反应性、压力调节、行为适应和大脑衰老的改变。
Mineralocorticoid (MR) and glucocorticoid receptors (GR) are expressed in the central nervous system. Radioligand binding studies, autoradiography, immunocytochemistry and in situ hybridization have shown that MR and GR are found in abundance in neurons of the limbic system (hippocampus), a structure involved in mood, affect and subtle control of the hypothalamic-pituitary-adrenal (HPA) axis. In the hippocampus MR binds corticosterone (CORT) as well as aldosterone (ALDO) with high affinity. MR seems mainly occupied by CORT in the face of its 2-3 order higher circulating concentration. GR binds CORT with a 6-10-fold lower affinity.MR and GR gene expression, as well as the native receptor proteins, seem to be controlled in a coordinative manner. When GR is down-regulated by excess homologous steroid, MR appears to be increased. Down regulation of MR reduces GR as well. MR and GR display a differential ontogenetic pattern. Ontogeny, particularly that of GR, can be permanently influenced when animals are exposed during the first post-natal week to maternal deprivation, handling, CORT or ACTH1-24 injections. These MR and GR changes persist into senescence and have been proposed to result in altered CORT responsiveness, stress regulation, behavioural adaptation and brain aging.