Controlled trials of synchronous chemotherapy with radiotherapy in head and neck cancer: overview of radiation morbidity.
Controlled trials of synchronous chemotherapy with radiotherapy in head and neck cancer: overview of radiation morbidity.
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DOI：
10.1016/s0936-6555(05)80064-0
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Henk, J M
中科院分区：
文献类型：
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作者：
Henk, J M
最近发表的头颈部鳞状细胞癌同步化疗与放疗随机对照试验概述表明，与单独放疗相比，联合治疗具有显着的生存优势。然而，他们还表明化疗会增加急性放射发病率，但没有关于后期影响的信息。 Munro 概述中包含的 19 篇同步化疗试验出版物的发病率数据进行了审查。研究发现，化疗显着增强了急性和晚期效应，表明这些药物可能只是剂量调整。未来的试验应旨在确定化疗是否可以提高治疗率。
Recently published overviews of randomized controlled trials of simultaneous chemotherapy with radiotherapy in squamous cell carcinoma of the head and neck have demonstrated a significant survival advantage from the combined treatment compared with radiotherapy alone. However, they also showed that chemotherapy increased acute radiation morbidity, but there was no information on late effects. The 19 publications of trials of simultaneous chemotherapy contained in the overview by Munro were reviewed for morbidity data. It was found that chemotherapy significantly enhanced both acute and late effects, suggesting that the drugs may be merely dose-modifying. Future trials should be designed to determine whether or not chemotherapy improves the therapeutic ratio.