Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency
Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency
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DOI：
10.3945/ajcn.2010.29306
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发表时间：
2010-12-01
影响因子：
7.1
通讯作者：
El Sohemv, Ahmed
中科院分区：
文献类型：
--
作者：
Cahill, Leah E.;El Sohemv, Ahmed
背景结合珠蛋白（由Hp基因编码）Hp是一种血红蛋白结合蛋白，具有抗氧化作用，其多态性由两个结构不同的等位基因Hp 1和Hp 2组成。Hp 2抑制氧化和维生素C消耗的能力低于Hp 1，但对维生素C需要量的影响尚不清楚。饮食中维生素C和血清抗坏血酸缺乏之间的关系（
Background Haptoglobin (which is encoded by the Hp gene) is a hemoglobin binding protein that has antioxidant properties and a common polymorphism that consists of 2 structurally different alleles Hp1 and Hp2 The capacity of Hp2 to inhibit oxidation and vitamin C depletion is less than that of Hp1 but the influence on vitamin C requirements remains unknownObjective This study aimed to determine whether the Hp poly morphism modifies the association between dietary vitamin C and serum ascorbic acid deficiency (