Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen
Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen
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DOI：
10.1002/chem.201602393
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发表时间：
2016-07-25
影响因子：
4.3
通讯作者：
Malcolmson, Steven J.
中科院分区：
文献类型：
--
作者：
Logan, Angus W. J.;Theis, Thomas;Malcolmson, Steven J.
具有热极化的核磁共振需要相对集中的样品，特别是对于低丰度和低旋磁比的核，如N-15。我们扩大了SABRE的底物范围，这是一种最近引入的超极化方法，允许访问N-15富集席夫碱。这些衬底显示出高达2%的分数N-15偏振能级，同时只有最小的H-1增强。
NMR with thermal polarization requires relatively concentrated samples, particularly for nuclei with low abundance and low gyromagnetic ratios, such as N-15. We expand the substrate scope of SABRE, a recently introduced hyperpolarization method, to allow access to N-15-enriched Schiff bases. These substrates show fractional N-15 polarization levels of up to 2% while having only minimal H-1 enhancements.