T-CELL ANTIGEN DEFICIENCIES AND CLONAL REARRANGEMENTS OF T-CELL RECEPTOR GENES IN PAGETOID RETICULOSIS (WORINGER-KOLOPP DISEASE)
T-CELL ANTIGEN DEFICIENCIES AND CLONAL REARRANGEMENTS OF T-CELL RECEPTOR GENES IN PAGETOID RETICULOSIS (WORINGER-KOLOPP DISEASE)
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DOI：
10.1056/nejm198801213180307
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发表时间：
1988-01-21
影响因子：
158.5
通讯作者：
SKLAR, J
中科院分区：
文献类型：
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作者：
WOOD, GS;WEISS, LM;SKLAR, J
PAGETOID网状细胞增多症（沃-科二氏病）是一种罕见的皮肤病，由孤立或局限的，常为过度角化的皮肤斑块组成。在组织学上，皮肤受累区域在增生的表皮内有明显的细胞学非典型单核细胞浸润。1，2临床上，这些病变是无痛性的。有报道称，在局部手术或放射治疗后，几名患者的病情得到了缓解;然而，其他患者表现为播散性的Pagetoid网状细胞增多症，即Ketron-Goodman变异型。2，3其中一些患者还出现了典型的蕈样肉芽肿病变，这是一种皮肤T细胞淋巴瘤，并已死亡。456.
PAGETOID reticulosis (Woringer-Kolopp disease) is a rare skin disorder consisting of solitary or localized, often hyperkeratotic, cutaneous plaques. Histologically, the involved areas of skin show a prominent infiltrate of cytologically atypical mononuclear cells within a hyperplastic epidermis.1,2Clinically, these lesions are indolent. There have been reports that the condition has resolved in several patients after local surgery or radiation therapy; however, other patients have presented with a disseminated form of pagetoid reticulosis, the Ketron-Goodman variant.2,3Some of these patients have also had typical lesions of mycosis fungoides, a form of cutaneous T-cell lymphoma, and have died.456The nature of the . . .