Osteogenesis capability and degradation property evaluation of injectable biomaterials: comparison of computed tomography and ultrasound
Osteogenesis capability and degradation property evaluation of injectable biomaterials: comparison of computed tomography and ultrasound
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DOI：
10.1155/2013/763937
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发表时间：
2013
影响因子：
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通讯作者：
Yan Chen;Yuting Yan;Xiaoming Li;He Li;Yue Yuan;Xiaoying Gao;Xixi Wu;Jisheng Zhong;
中科院分区：
文献类型：
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作者：
Yan Chen;Yuting Yan;Xiaoming Li;He Li;Yue Yuan;Xiaoying Gao;Xixi Wu;Jisheng Zhong;
可注射的生物材料，它可以物理插入到一个目标位置，而不使用手术，在过去的十年中，在组织工程中受到越来越多的关注。对可注射生物材料的直接和非侵入性定量评价的需求也在不断增长。本研究的目的是建立一种定量的无创技术来评价原位形成的骨生物材料，并验证诊断超声图像分析技术的可行性。将超声用于定量评价组织发育的潜力与体内计算机断层扫描（CT）进行了比较。超声灰阶值（GV）与CT容积平均值（HUm）之间存在较强的相关性（r = 0.95）。同时，利用超声最大截面像素值可以估计出肿瘤区域的体积，与三维重建图像中的CT掩模体积具有一定的一致性（r = 0.87）。超声成像技术与传统的CT技术相对应，可用于评价可注射生物材料的成骨能力和降解性能。它可能是一种非侵入性，非放射性，和有效的援助，以监测骨化和重建的生物材料在植入区域的骨缺损修复。
Injectable biomaterials, which can be physically inserted into a target site without the use of surgery, have received increasing attention in tissue engineering during the last decade. There is also a growing need for quantitative evaluation of the injectable biomaterial directly and noninvasively. The objectives of this study are to originate a quantitative noninvasive technique for evaluation of in situ forming bone biomaterials and to validate the feasibility of diagnostic ultrasound images analysis technique. The potential of ultrasound for quantitative evaluation of tissue development was compared with computed tomography (CT) in vivo. A strong correlation was witnessed between ultrasound gray-scale values (GV) and volumetric mean of CT value (HUm) (r = 0.95). Meanwhile, the volume of the material area could be estimated by ultrasound maximum cross-section pixel, which demonstrates a certain consistency with CT mask volume in 3D reconstruction images (r = 0.87). In conclusion, ultrasound imaging, which is corresponding with the traditional CT, can be used to evaluate osteogenesis capability and degradation property of injectable biomaterials. It may be a noninvasive, nonradioactive, and effective aid to monitor ossification and reconstruction of biomaterials at the implant region for bone defect repair.