Emerging concepts in the epidemiology, pathophysiology, and clinical care of osteoporosis across the menopausal transition
Emerging concepts in the epidemiology, pathophysiology, and clinical care of osteoporosis across the menopausal transition
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DOI：
10.1016/j.matbio.2018.05.001
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发表时间：
2018-10-01
期刊：
影响因子：
6.9
通讯作者：
Zaidi, Mone
中科院分区：
文献类型：
--
作者：
Lizneva, Daria;Yuen, Tony;Zaidi, Mone
女性的骨质流失在围绝经期加速，并持续到老年。迄今为止，在绝经前和绝经后早期妇女骨折风险分层方面几乎没有取得进展。流行病学数据表明，血清FSH的变化可以预测绝经前后骨量的减少。在骨中，FSH通过释放破骨细胞生成细胞因子刺激破骨细胞形成。在这里，我们解决绝经过渡期骨丢失的证据，讨论绝经后早期骨质疏松症的检测和治疗策略，并描述FSH在生理学和可能在绝经后早期骨丢失的病理生理学中的作用。(C)2018由Elsevier B.V.出版
Bone loss in women accelerates during perimenopause, and continues into old age. To-date, there has been little progress made in stratifying for fracture risk in premenopausal and early postmenopausal women. Epidemiologic data suggests that changes in serum FSH could predict decrements in bone mass during peri- and postmenopause. In bone, FSH stimulates osteoclast formation by releasing osteoclastogenic cytokines. Here, we address the evidence for bone loss across the menopausal transition, discuss strategies for detection and treatment of early postmenopausal osteoporosis, and describe the role FSH plays in physiology and likely in pathophysiology of early postmenopausal bone loss. (C) 2018 Published by Elsevier B.V.