Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.
Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human.
复制标题
低分子量、钙依赖性磷脂酶 A2 基因与小鼠和人类的同源染色体区域相连并定位。
DOI：
10.1006/geno.1996.0126
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发表时间：
1996
期刊：
影响因子：
4.4
通讯作者：
Lusis,AJ
中科院分区：
文献类型：
--
作者：
Tischfield,JA;Xia,YR;Shih,DM;Klisak,I;Chen,J;Engle,SJ;Siakotos,AN;Winstead,MV;Seilhamer,JJ;Allamand,V;Gyapay,G;Lusis,AJ
The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34–p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the distal part of chromosome 4, a region exhibiting synteny with human 1p34–p36. Unlike its rodent counterpart, humanPLA2G2Cappears to be a nonfunctional pseudogene.
