p21 rs3176352 G>C and p73 rs1801173 C>T polymorphisms are associated with an increased risk of esophageal cancer in a Chinese population.
p21 rs3176352 G>C and p73 rs1801173 C>T polymorphisms are associated with an increased risk of esophageal cancer in a Chinese population.
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p21 rs3176352 G>C 和 p73 rs1801173 C>T 多态性与中国人群食管癌风险增加相关。
DOI：
10.1371/journal.pone.0096958
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Gu H
中科院分区：
文献类型：
--
作者：
Zheng L;Tang W;Shi Y;Chen S;Wang X;Wang L;Shao A;Ding G;Liu C;Liu R;Yin J;Gu H
Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis. To evaluate the effect p21, p53, TP53BP1 and p73 single nucleotide polymorphisms (SNPs) on the risk of ESCC, we conducted a hospital based case–control study. A total of 629 ESCC cases and 686 controls were recruited. Their genotypes were determined using ligation detection reaction (LDR) method. When the p21 rs3176352 GG homozygote genotype was used as the reference group, the CC genotype was associated with a significantly increased risk of ESCC. When the p73 rs1801173 CC homozygote genotype was used as the reference group, the CT genotype was associated with a significantly increased risk of ESCC. After Bonferroni correction, for p21 rs3176352 G>C, the p correct was still significant. For the other six SNPs, in all comparison models, no association between the polymorphisms and ESCC risk was observed. p21 rs3176352 G>C and p73 rs1801173 C>T SNPs are associated with increased risk of ESCC. To confirm the current findings, additional, larger studies and tissue-specific biological characterization are required.
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影响因子：
30.8
作者：
Dumont, P;Leu, JIJ;Murphy, M
通讯作者：
Murphy, M
DOI：
10.18632/aging.100425
发表时间：
2012-01
期刊：
Aging
影响因子：
--
作者：
Altilia S;Santoro A;Malagoli D;Lanzarini C;Ballesteros Álvarez JA;Galazzo G;Porter DC;Crocco P;Rose G;Passarino G;Roninson IB;Franceschi C;Salvioli S
通讯作者：
Salvioli S
影响因子：
64.5
作者：
ELDEIRY, WS;TOKINO, T;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
2.6
作者：
Ge, H.;Wang, Y.-M.;Zhang, J.-H.
通讯作者：
Zhang, J.-H.
影响因子：
8.8
作者：
Sinilnikova, O. M.;Antoniou, A. C.;Stoppa-Lyonnet, D.
通讯作者：
Stoppa-Lyonnet, D.