Ultrasound-guided drug delivery in cancer.
Ultrasound-guided drug delivery in cancer.
复制标题
DOI：
10.14366/usg.17021
复制
发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Willmann JK
中科院分区：
文献类型：
--
作者：
Mullick Chowdhury S;Lee T;Willmann JK
超声和微泡（USMB）介导的药物递送技术的最新进展表明，这种方法可以改善药物和基因向靶组织的空间限制递送，同时降低全身剂量和毒性。增强治疗剂递送的机制是声孔效应，即由超声触发的振荡和微泡的破坏诱导的脉管系统中开口的形成。本文综述了近年来USMB介导的药物传递的研究进展和面临的挑战，并重点介绍了USMB在肿瘤治疗中的应用。
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.