Verbal fluency as a prefrontal activation probe:: a validation study using 99mTc-ECD brain SPET
Verbal fluency as a prefrontal activation probe:: a validation study using 99mTc-ECD brain SPET
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DOI：
10.1007/s002590000351
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发表时间：
2000-12-01
期刊：
影响因子：
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通讯作者：
Dierckx, R
中科院分区：
文献类型：
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作者：
Audenaert, K;Brans, B;Dierckx, R
本研究旨在探讨在健康志愿者中进行控制口头词语联想（COWA）测试的字母和类别流畅性范式下脑单光子发射断层扫描（SPET）的可行性。两组各由10名右利手健康志愿者组成，按照分剂量模式（静息和激活状态）注射两次370兆贝克勒尔的锝 - 99m双半胱乙酯。采用统计参数映射（SPM96）来确定体素水平的显著变化。字母流畅性和类别流畅性激活范式具有不同的大脑激活模式。在两种范式中，左侧额下回后部（LIPC）均被激活，类别流畅性任务在左侧额下回前部有额外激活。在类别流畅性任务中，但在字母流畅性任务中未发现，右侧额下回被激活。这些发现在很大程度上证实了先前在语义和语音激活范式中进行的功能磁共振成像和正电子发射断层扫描研究的结果。对导致这些结果的实验设计的各种方法学特征的选择和有效性进行了批判性讨论。结论是，在健康志愿者的标准神经心理学条件下，采用字母流畅性和类别流畅性范式进行脑SPET激活在技术和实践上都是可行的。
This study aimed to investigate the feasibility of brain single-photon emission tomography (SPET) in the letter and category fluency paradigm of the Controlled Oral Word Association (COWA) test in healthy volunteers. Two groups each comprising ten right-handed healthy volunteers were injected twice with 370 MBq technetium-99m ethyl cysteinate dimer following a split-dose paradigm (resting and activation condition). Statistical parametric mapping (SPM96) was used to determine voxelwise significant changes. The letter fluency and the category fluency activation paradigm had a differential brain activation pattern. The posterior part of the left inferior prefrontal cortex (LIPC) was activated in both paradigms, with the category fluency task having an extra activation in the anterior LIPC. In the category fluency task, but not the letter fluency task, an activation in the right inferior prefrontal cortex was found. These findings confirm to a large extent the results of previous functional magnetic resonance imaging and positron emission tomography studies in semantic and phonological activation paradigms. The choice and validity of various methodological characteristics of the experimental design leading to these results are critically discussed. It is concluded that brain SPET activation with the letter fluency and category fluency paradigm under standard neuropsychological conditions in healthy volunteers is both technically and practically feasible.