Transmission of a 2009 Pandemic Influenza Virus Shows a Sensitivity to Temperature and Humidity Similar to That of an H3N2 Seasonal Strain
Transmission of a 2009 Pandemic Influenza Virus Shows a Sensitivity to Temperature and Humidity Similar to That of an H3N2 Seasonal Strain
复制标题
DOI：
10.1128/jvi.02186-10
复制
发表时间：
2011-02-01
影响因子：
5.4
通讯作者：
Lowen, Anice C.
中科院分区：
文献类型：
--
作者：
Steel, John;Palese, Peter;Lowen, Anice C.
在世界上的温带地区，流感流行遵循高度规律的季节性模式，活动在仲冬达到高峰。与这种流行病学相一致，我们以前已经表明，季节性H3N2流感病毒的气溶胶传播在寒冷干燥的条件下最有效。随着2009年H1N1流感大流行，出现了流感标准季节性的一个例外：2009年期间，在北方半球，春季和夏季的流感病毒活动水平异常高，随后是一场广泛的流行病，在10月下旬达到高峰，比平常早了大约2.5个月。在此，我们发现，2009年大流行株的气溶胶传播显示出对相对湿度和温度的依赖性，与季节性H3N2流感病毒非常相似。我们的数据表明，观察到的不同季节爆发时间的差异很可能不是由于大流行性H1N1和季节性H3N2流感病毒之间传播的内在差异。
In temperate regions of the world, influenza epidemics follow a highly regular seasonal pattern, in which activity peaks in midwinter. Consistently with this epidemiology, we have shown previously that the aerosol transmission of a seasonal H3N2 influenza virus is most efficient under cold, dry conditions. With the 2009 H1N1 pandemic, an exception to the standard seasonality of influenza developed: during 2009 in the Northern Hemisphere, an unusually high level of influenza virus activity over the spring and summer months was followed by a widespread epidemic which peaked in late October, approximately 2.5 months earlier than usual. Herein we show that aerosol transmission of a 2009 pandemic strain shows a dependence on relative humidity and temperature very similar to that of a seasonal H3N2 influenza virus. Our data indicate that the observed differences in the timings of outbreaks with regard to the seasons are most likely not due to intrinsic differences in transmission between the pandemic H1N1 and seasonal H3N2 influenza viruses.