Monocular myopic defocus and daily changes in axial length and choroidal thickness of human eyes
Monocular myopic defocus and daily changes in axial length and choroidal thickness of human eyes
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DOI：
10.1016/j.exer.2012.08.002
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Collins, Michael J.
中科院分区：
文献类型：
--
作者：
Chakraborty, Ranjay;Read, Scott A.;Collins, Michael J.
最近的研究表明，短暂的单眼离焦(60分钟)会导致人体眼轴长度发生微小但显著的变化。然而，较长时间的离焦对人眼轴长的影响尚不清楚。我们研究了12小时的单眼近视离焦对青年正视眼眼轴长度和脉络膜厚度的自然日变化的影响。对13名正视眼青壮年连续3天进行了眼轴长度和脉络膜厚度的测量(每隔3小时测量一次，第一次测量在上午9点左右，最后一次测量在晚上9点左右)。分别检测自然昼夜节律(第1天，基线日，无散焦)、单眼近视散焦的日节律(第2天，散焦日，右眼上方+1.50DS眼镜镜片)，以及对任何离焦引起的变化的恢复情况(第3天，恢复日，无散焦)。在三个测量日中的每一天，眼轴长度和脉络膜厚度都有显著的变化(p<；0.0001)。随着单眼近视散焦的发生，眼轴长度和脉络膜厚度的日变化的大小和时间在第2天显著改变(p<；0.0001)。在引入单眼近视离焦后，眼轴长度的每日峰值出现在大约6h后，脉络膜厚度的峰值出现在当天大约8.5h，而与第1天和第3天(没有离焦)相比，脉络膜厚度的峰值提前了约8.5h。眼轴变化的平均波幅(第1天为0.030+/-0.012，第2天为0.020+/-0.010，第3天为0.033+/-0.012 mm)和脉络膜厚度变化的平均幅度(第1天为0.030+/-0.007，第2天为0.022+/-0.006，第3天为0.027±-0.009 mm)也有显著差异(P均<0.05)。单眼近视离焦的引入打乱了人眼眼轴长度和脉络膜厚度的每日变化(在幅度和时间方面)，这些变化在移除离焦后的第二天恢复正常。(C)2012爱思唯尔有限公司。保留所有权利。
Recent research indicates that brief periods (60 min) of monocular defocus lead to small but significant changes in human axial length. However, the effects of longer periods of defocus on the axial length of human eyes are unknown. We examined the influence of a 12 h period of monocular myopic defocus on the natural daily variations occurring in axial length and choroidal thickness of young adult emmetropes. A series of axial length and choroidal thickness measurements (collected at similar to 3 hourly intervals, with the first measurement at similar to 9 am and the final measurement at similar to 9 pm) were obtained for 13 emmetropic young adults over three consecutive days. The natural daily rhythms (Day 1, baseline day, no defocus), the daily rhythms with monocular myopic defocus (Day 2, defocus day, +1.50 DS spectacle lens over the right eye), and the recovery from any defocus induced changes (Day 3, recovery day, no defocus) were all examined. Significant variations over the course of the day were observed in both axial length and choroidal thickness on each of the three measurement days (p < 0.0001). The magnitude and timing of the daily variations in axial length and choroidal thickness were significantly altered with the monocular myopic defocus on day 2 (p < 0.0001). Following the introduction of monocular myopic defocus, the daily peak in axial length occurred approximately 6 h later, and the peak in choroidal thickness approximately 8.5 h earlier in the day compared to days 1 and 3 (with no defocus). The mean amplitude (peak to trough) of change in axial length (0.030 +/- 0.012 on day 1, 0.020 +/- 0.010 on day 2 and 0.033 +/- 0.012 mm on day 3) and choroidal thickness (0.030 +/- 0.007 on day 1, 0.022 +/- 0.006 on day 2 and 0.027 +/- 0.009 mm on day 3) were also significantly different between the three days (both p < 0.05). The introduction of monocular myopic defocus disrupts the daily variations in axial length and choroidal thickness of human eyes (in terms of both amplitude and timing) that return to normal the following day after removal of the defocus. (c) 2012 Elsevier Ltd. All rights reserved.