Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.
Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.
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人体淋巴器官和各种分泌组织中IgA产生细胞的不同亚类分布。
DOI：
10.4049/jimmunol.136.10.3631
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发表时间：
1986
影响因子：
4.4
通讯作者：
J. Haaijman
中科院分区：
文献类型：
--
作者：
K. Kett;P. Brandtzaeg;J. Rádl;J. Haaijman
采用高重复性配对免疫荧光染色法绘制IgA1和iga2生成细胞在外周血淋巴器官和各种分泌组织中的相对分布。脾脏、外周淋巴结和扁桃体中IgA1免疫细胞均占明显优势（91% ~ 95%）。然而，分泌组织中产生iga1细胞的中位数比例存在显著差异：鼻黏膜，96%；泪腺，81%；大唾液腺占66%；乳腺，63%；胃及近端小肠黏膜占84 ~ 77%；回肠,55%;大肠，41%。因此，IgA2的产生主要在远端肠道、乳腺和唾液腺中相对增强。
A highly reproducible paired immunofluorescence staining method was used to map the relative distribution of IgA1- and IgA2-producing cells in peripheral lymphoid organs and various secretory tissues. Spleen, peripheral lymph nodes, and tonsils all contained a marked predominance (91 to 95%) of IgA1 immunocytes. However, striking variations were demonstrated among the secretory tissues with regard to the median proportion of IgA1-producing cells: nasal mucosa, 96%; lacrimal glands, 81%; major salivary glands, 66%; mammary glands, 63%; gastric and proximal small intestinal mucosa, 84 to 77%; ileum, 55%; and large bowel, 41%. Thus, IgA2 production is relatively enhanced mainly in the distal gut and in mammary and salivary glands, in that order.