Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation.
Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation.
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DOI：
10.1016/j.mam.2017.04.003
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发表时间：
2017-12
影响因子：
10.6
通讯作者：
Levy BD
中科院分区：
文献类型：
--
作者：
Duvall MG;Bruggemann TR;Levy BD
支气管每天都暴露在刺激物、微生物和过敏原以及极端的温度和酸中。气道粘膜上皮作为哨兵发挥着关键作用，在遇到危险时释放警报。为了维持体内平衡，需要一个复杂的反调控信号网络和细胞效应机制。专门的促解决介质（SPMs）是在损伤、感染或过敏反应中制定解决程序的化学介质。SPMs是由必需的多不饱和脂肪酸酶促衍生的，具有有效的细胞特异性免疫解决特性。SPMs通过参与基于细胞的受体来关闭急性炎症反应并恢复组织稳态。几种常见的肺部疾病，包括哮喘、慢性阻塞性肺疾病（COPD）和囊性纤维化（CF），其特征是未解决的支气管炎症。在肺疾病的临床前小鼠模型中，SPMs具有有效的支气管保护作用。在这里，我们回顾了spm在肺中的细胞和分子效应及其在人体内的翻译。
Bronchi are exposed daily to irritants, microbes and allergens as well as extremes of temperature and acid. The airway mucosal epithelium plays a pivotal role as a sentinel, releasing alarmins when danger is encountered. To maintain homeostasis, an elaborate counter-regulatory network of signals and cellular effector mechanisms are needed. Specialized pro-resolving mediators (SPMs) are chemical mediators that enact resolution programs in response to injury, infection or allergy. SPMs are enzymatically derived from essential polyunsaturated fatty acids with potent cell-type specific immunoresolvent properties. SPMs signal by engaging cell-based receptors to turn off acute inflammatory responses and restore tissue homeostasis. Several common lung diseases involving the airways, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF), are characterized by unresolved bronchial inflammation. In preclinical murine models of lung disease, SPMs carry potent bronchoprotective actions. Here, we review cellular and molecular effects for SPM-initiated catabasis in the lung and their human translation.
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影响因子：
64.8
作者：
Chiang, Nan;Fredman, Gabrielle;Backhed, Fredrik;Oh, Sungwhan F.;Vickery, Thad;Schmidt, Birgitta A.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
影响因子：
5.8
作者：
Bhavsar PK;Levy BD;Hew MJ;Pfeffer MA;Kazani S;Israel E;Chung KF
通讯作者：
Chung KF
DOI：
10.1084/jem.20150225
发表时间：
2015-07-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chiang N;Dalli J;Colas RA;Serhan CN
通讯作者：
Serhan CN
影响因子：
5.2
作者：
Chiron, Raphael;Grumbach, Y. Yael;Urbach, Valerie
通讯作者：
Urbach, Valerie
DOI：
10.1073/pnas.052533799
发表时间：
2002-03-19
影响因子：
11.1
作者：
Canny, G;Levy, O;Colgan, SP
通讯作者：
Colgan, SP