Chromosomal rearrangements during human epidermal keratinocyte differentiation.
Chromosomal rearrangements during human epidermal keratinocyte differentiation.
复制标题
人表皮角质形成细胞分化过程中的染色体重排。
DOI：
10.1002/jcp.21855
复制
发表时间：
2009
影响因子：
5.6
通讯作者：
Berezney,Ronald
中科院分区：
文献类型：
--
作者：
Marella,NarasimharaoV;Seifert,Brandon;Nagarajan,Priyadharsini;Sinha,Satrajit;Berezney,Ronald
Undifferentiated human epidermal keratinocytes are self‐renewing stem cells that can be induced to undergo a program of differentiation by varying the calcium chloride concentration in the culture media. We utilize this model of cell differentiation and a 3D chromosome painting technique to document significant changes in the radial arrangement, morphology, and interchromosomal associations between the gene poor chromosome 18 and the gene rich chromosome 19 territories at discrete stages during keratinocyte differentiation. We suggest that changes observed in chromosomal territorial organization provides an architectural basis for genomic function during cell differentiation and provide further support for achromosome territory codethat contributes to gene expression at the global level. J. Cell. Physiol. J. Cell. Physiol. 221: 139–146, 2009. © 2009 Wiley‐Liss, Inc.
