Role of iron in microbe-host interactions.
Role of iron in microbe-host interactions.
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铁在微生物-宿主相互作用中的作用。
DOI：
10.1093/clinids/5.supplement_4.s759
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
McIntosh,MA
中科院分区：
文献类型：
--
作者：
Finkelstein,RA;Sciortino,CV;McIntosh,MA
希望生活在哺乳动物宿主体内或宿主上的微生物获取铁的能力是宿主与寄生虫相互作用的关键决定因素。尽管铁含量丰富，但其对微生物的有效性受到宿主铁结合和运输系统的限制。因此，成功的共生或病原体必须表达有效的系统来竞争其铁。因此，铁的获取对毒力是必要的，尽管不是充分的。这篇综述考察了宿主和微生物铁的获取和运输机制，试图激发读者对潜在的“软点”的兴趣，这些“软点”可以用于预防和治疗。
The ability of microorganisms that would like to live in or on mammalian hosts to acquire iron is a critical determinant of the host-parasite interaction. Despite the abundance of iron, its availability to microbes is restricted by the iron-binding and transport systems of the host. The successful commensal or pathogen therefore must express effective systems to compete for its iron. The acquisition of iron is thus essential, although not sufficient, for virulence. This review examines host and microbial iron-acquisition and transport mechanisms in an attempt to stimulate the reader's interest in potential “soft spots” that may be exploited prophylactically and therapeutically.