Human RAS superfamily proteins and related GTPases.
Human RAS superfamily proteins and related GTPases.
复制标题
DOI：
10.1126/stke.2502004re13
复制
发表时间：
2004-09-07
期刊：
影响因子：
--
通讯作者：
Colicelli, John
中科院分区：
文献类型：
--
作者：
Colicelli, John
肿瘤癌蛋白HRAS、KRAS和NRAS是至少35种相关人类蛋白质的更大家族的创始成员。使用更广泛的定义序列相似性揭示了一个更广泛的超家族超过170 RAS相关蛋白。GTP（鸟苷三磷酸）水解偶联的信号转导中继蛋白的RAS超家族可以被细分为RAS、RHO、RAB和ARF家族，以及密切相关的Ga家族。每个家族的成员可以依次排列成进化上保守的分支。这些分组反映了结构、生物化学和功能的保守性。最近的研究结果提供了见解的信号特征的代表性成员的RAS超家族分支。这里提出的分析可以作为一个指导，预测许多未表征的超家族成员的功能。还描述了与RAS超家族成员不同的鸟苷三磷酸酶（GTP酶）。这些相关蛋白质在不同的结构背景下采用GTP结合和GTP酶域，扩大了它们在人类中的功能范围。
The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger family of at least 35 related human proteins. Using a somewhat broader definition of sequence similarity reveals a more extended superfamily of more than 170 RAS-related proteins. The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related Galpha family. The members of each family can, in turn, be arranged into evolutionarily conserved branches. These groupings reflect structural, biochemical, and functional conservation. Recent findings have provided insights into the signaling characteristics of representative members of most RAS superfamily branches. The analysis presented here may serve as a guide for predicting the function of numerous uncharacterized superfamily members. Also described are guanosine triphosphatases (GTPases) distinct from members of the RAS superfamily. These related proteins employ GTP binding and GTPase domains in diverse structural contexts, expanding the scope of their function in humans.