Influence of oestrous cycle and pregnancy on the reactivity of the rat mesenteric vascular bed.
Influence of oestrous cycle and pregnancy on the reactivity of the rat mesenteric vascular bed.
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发情周期和妊娠对大鼠肠系膜血管床反应性的影响。
作者：
J. D. Dalle Lucca;A. Adeagbo;N. L. Alsip
In isolated, perfused mesenteric vascular beds from female rats, it was assessed whether the constrictor response to cirazoline, an alpha(1)-adrenergic agonist, or acetylcholine (ACh)-induced relaxation was altered by oestrous cycle or pregnancy and the ability of nitric oxide (NO), prostanoids and endothelium-derived hyperpolarizing factor (EDHF) to modulate these responses. Mesenteries, removed from female rats on each oestrous cycle day and gestation day 16, were perfused with physiological salt solution. Tone was induced with cirazoline (1 micromol/l), and concentration-response curves to ACh generated. Responsiveness to ACh was tested in the presence of N(omega)-nitro-L-arginine (L-NA), ibuprofen (IBU) and tetrabutylammonium (TBA), to inhibit nitric oxide synthase (NOS), cyclo-oxygenase and K(+) channels respectively. Cirazoline-induced tone was smaller in pro-oestrous and pregnant groups, but the increase in tone to L-NA was larger in pregnant compared with oestrous and dioestrous groups. Control responses to ACh were not different, but L-NA attenuated the response in virgin groups only. IBU did not affect the ACh response, but TBA attenuated it in all groups. When TBA was introduced first, ACh-induced dilatation was significantly reduced and not altered by L-NA addition. These results suggest that in the mesenteric vascular bed from cycling and pregnant rats, EDHF is the major mediator of ACh-induced dilatation and NOS may be up-regulated in pregnant and pro-oestrous rats.
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雌激素增加雄性大鼠主动脉内皮细胞 (RAEC) PGI2 的释放。
DOI：
10.1016/s0952-3278(96)90023-x
发表时间：
1996
期刊：
Prostaglandins, leukotrienes, and essential fatty acids
影响因子：
--
作者：
Myers,SI;Turnage,RH;Bartula,L;Kalley,B;Meng,Y
通讯作者：
Meng,Y
怀孕大鼠肠系膜微血管的收缩和内皮依赖性松弛。
DOI：
10.1152/ajpheart.1995.269.6.h1899
发表时间：
1995
期刊：
The American journal of physiology.
影响因子：
--
作者：
Pascoal,IF;Lindheimer,MD;Nalbantian-Brandt,C;Umans,JG
通讯作者：
Umans,JG
影响因子：
20.1
作者：
Campbell, WB;Gebremedhin, D;Harder, DR
通讯作者：
Harder, DR
体内雌激素对灌注兔心脏冠状血管阻力的影响。
DOI：
10.1152/ajpregu.1995.269.6.r1333
发表时间：
1995
期刊：
The American journal of physiology.
影响因子：
--
作者：
Gorodeski,GI;Yang,T;Levy,MN;Goldfarb,J;Utian,WH
通讯作者：
Utian,WH
妊娠对大鼠股骨微血管反应的影响。
影响因子：
9.8
作者：
Yamasaki,M;Lindheimer,MD;Umans,JG
通讯作者：
Umans,JG