Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study
Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study
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DOI：
10.1038/oby.2011.47
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发表时间：
2011-10-01
期刊：
影响因子：
6.9
通讯作者：
Venn, Alison J.
中科院分区：
文献类型：
--
作者：
Curry, Beverley A.;Blizzard, C. Leigh;Venn, Alison J.
据报道，儿童BMI与成人肺功能呈正相关。本研究的目的是调查儿童BMI对年轻成人肺功能的影响，而不受瘦体重（LBM）的影响。临床和问卷调查数据收集自654名澳大利亚年轻成年人（年龄27-36岁），首次研究时年龄为9岁，12岁或15岁。采用用力肺活量（FVC）、1秒用力呼气容积（FEV 1）、FEV 1/FVC比值、用力呼气流量（FEF 25 -75）等指标测定肺功能。BMI和LBM来自基线（1985年）和随访（2004-2006年）时的人体测量。多变量模型被用来研究儿童期年龄和性别标准化BMI对成人肺功能的影响，在调整LBM之前和之后。成人肥胖对肺功能有很强的有害影响，与儿童期BMI无关，调整儿童期LBM消除了儿童期BMI对成人FEV 1或FVC的任何明显有益影响。这表明，在先前的纵向研究中观察到的儿童期BMI增加对成人FEV 1和FVC的有益影响可能归因于儿童期LBM增加，而不是肥胖。肥胖儿童成为肥胖成年人可能比那些保持健康体重的人具有更差的肺功能，但肺功能的大缺陷也可能是健康体重儿童成为肥胖成年人的原因。这就凸显了终身保持健康体重的重要性。
Childhood BMI has been reported to be positively associated with adult lung function. The aim of this study was to investigate the effect of childhood BMI on young adult lung function independently of the effects of lean body mass (LBM). Clinical and questionnaire data were collected from 654 young Australian adults (aged 27-36 years), first studied when age 9, 12, or 15 years. Adult lung function was measured by forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, and the forced expiratory flow in the middle 50% of FVC (FEF25-75). BMI and LBM were derived from anthropometric measures at baseline (1985) and at follow-up (2004-2006). Multivariable models were used to investigate the effect of age and sex standardized BMI in childhood on adult lung function, before and after adjustment for LBM. Adult adiposity had a strong deleterious effect on lung function, irrespective of childhood BMI, and adjustment for childhood LBM eliminated any apparent beneficial effect of childhood BMI on adult FEV1 or FVC. This suggests that the beneficial effect of increased BMI in childhood on adult FEV1 and FVC observed in previous longitudinal studies is likely to be attributable to greater childhood LBM not adiposity. Obese children who become obese adults can expect to have poorer lung function than those who maintain healthy weight but large deficits in lung function are also likely for healthy weight children who become obese adults. This highlights the importance of lifetime healthy weight maintenance.