The tau gene haplotype h1 confers a susceptibility to Parkinson's disease.
The tau gene haplotype h1 confers a susceptibility to Parkinson's disease.
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tau 基因单倍型 h1 赋予帕金森病易感性。
DOI：
10.1159/000082956
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发表时间：
2005
影响因子：
2.4
通讯作者：
Fan,Dongsheng
中科院分区：
文献类型：
--
作者：
Zhang,Jun;Song,Yiqing;Chen,Honglei;Fan,Dongsheng
背景：thetaugene的多态性可能与原发性帕金森病（PD）的风险增加有关;然而，大多数先前的关联研究都没有足够的能力来检测thetauvariants对PD risk.Objective的潜在贡献：为了阐明thetaugene的遗传变异与PD风险之间的关系，我们对所有已发表的关联研究进行了荟萃分析。我们确定了14项独立的病例对照研究，包括2，093例PD病例和2，258例对照。在排除了两项对研究间异质性有贡献的研究后，H1/H1基因型与所有其他基因型相比，PD的合并优势比（OR）和95%置信区间（CI）为1.42（95%CI，1.23-1.65），所有携带H1单倍型的个体与所有其他个体相比，PD的合并优势比（OR）和95%置信区间（CI）为1.52（95%CI，1.12-2.04）。根据现有的数据，结果没有显着差异，根据性别，PD家族史，发病年龄和痴呆status.Conclusions：我们的研究结果支持的概念，Tau基因H1单倍型可能是一个重要的危险因素PD。
Background:Polymorphisms in thetaugene may be associated with increased risk for idiopathic Parkinson’s disease (PD); however, most of previous association studies have been underpowered to detect a potentially modest contribution of thetauvariants to PD risk.Objective:To clarify the relationship between genetic variation intaugene and PD risk, we conducted a meta-analysis of all published association studies. We identified 14 independent case-control studies including 2,093 PD cases and 2,258 controls. After excluding two studies contributing to most of between-study heterogeneity, the pooled odds ratios (OR) and 95% confidence intervals (CI) of PD were 1.42 (95% CI, 1.23–1.65) for those with H1/H1 genotype compared with all others and 1.52 (95% CI, 1.12–2.04) for all individuals carrying H1 haplotype versus all others. Based on the data available, the results were not significantly different according to sex, family history of PD, age at onset and dementia status.Conclusions:Our results support the notion thattaugene H1 haplotype may be an important risk factor of PD.