High Thyroid Stimulating Hormone Level Is Associated With Hyperandrogenism in Euthyroid Polycystic Ovary Syndrome (PCOS) Women, Independent of Age, BMI, and Thyroid Autoimmunity: A Cross-Sectional Analysis
High Thyroid Stimulating Hormone Level Is Associated With Hyperandrogenism in Euthyroid Polycystic Ovary Syndrome (PCOS) Women, Independent of Age, BMI, and Thyroid Autoimmunity: A Cross-Sectional Analysis
复制标题
高促甲状腺激素水平与甲状腺功能正常的多囊卵巢综合征 (PCOS) 女性的高雄激素血症相关，与年龄、体重指数和甲状腺自身免疫无关：横断面分析
DOI：
10.3389/fendo.2019.00222
复制
发表时间：
2019-04-10
影响因子：
5.2
通讯作者：
Tao, Tao
中科院分区：
文献类型：
--
作者：
Cai, Jie;Zhang, Yi;Tao, Tao
背景：多囊卵巢综合征(PCOS)患者和甲状腺功能障碍患者均常出现不孕症和血脂异常。关于甲状腺功能正常的PCOS妇女促甲状腺激素(TSH)水平与表型之间关系的有限研究。我们的目的是确定TSH水平的变化是否与正常甲状腺PCOS患者的表型有关。方法：对上海交通大学仁济医院2010-01/2018-08收治的600例多囊卵巢综合征患者和200例年龄、体重指数、甲状腺自身免疫相匹配的女性进行横断面研究。检测与促甲状腺激素、甲状腺自身免疫、血脂和性激素有关的人体测量和血清生化参数。结果：PCOS组促甲状腺激素水平(2.29±1.24vs.1.86±0.90mU/L，p<；0.001)明显高于对照组。在甲状腺功能正常的PCOS患者中，TSH、TG、TC、LDL-c和apoB水平从非高雄激素血症(Non-HA)到高雄激素血症(HA)组升高(均P<0.05)。TSH水平与TG、apoB、游离T、FAI呈正相关，与apoA呈负相关(均P<0.05)。在促甲状腺激素水平的基础上，透明质酸的比例有所增加(57.93%，TSH+GT2.5亩/L组为69.46%，p=0.006)。HA表型随TSH水平升高而增加，与年龄、BMI、WC、低密度脂蛋白胆固醇无关。多因素Logistic回归分析显示，TSH、TG与HA表型显著相关。结论：在甲状腺功能正常的PCOS患者中，高TSH水平与HA表型的增加有关，与年龄、体重指数和甲状腺自身免疫无关。
Background: Infertility and dyslipidemia are frequently present in both women with polycystic ovary syndrome (PCOS) and subjects with thyroid dysfunction. Limited study regarding the association between thyroid stimulating hormone (TSH) level and phenotypes in euthyroid PCOS women. We aimed to determine whether the variation of TSH level associates with phenotypes in euthyroid PCOS patients. Methods: Cross-sectional study including 600 PCOS and 200 age, body mass index (BMI), and thyroid autoimmunity-matched Chinese women from Renji hospital, Shanghai Jiaotong university during January 2010 and August 2018. The anthropometric and serum biochemical parameters related to TSH, thyroid autoimmunity, lipid profiles, and sex steroids were detected. Results: The TSH level is higher in (2.29 ± 1.24 vs. 1.86 ± 0.90 mu/L, p < 0.001) in PCOS than controls. In euthyroid PCOS patients, TSH, TG, TC, LDL-c, and apoB level increased from non-hyperandrogenism (nonHA) to HA group (all p < 0.05). TSH level is positively associated with TG, apoB, free T, FAI, and negatively associated with apoA (all p < 0.05). The percentage of HA increased from TSH level (57.93% in TSH < = 2.5 group vs. 69.46% in TSH > 2.5 mU/L group, p = 0.006). HA phenotype is increased with TSH level independently of age, BMI, WC, LDL-C. Besides, in multivariate logistic regression analysis TSH and TG significantly associated with HA phenotype. Conclusions: Higher TSH level is associated with increased prevalence of HA phenotype independent of age, BMI and thyroid autoimmunity in euthyroid PCOS.