Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet
Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet
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DOI：
10.1016/s0006-8993(02)02493-9
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发表时间：
2002-05-17
期刊：
影响因子：
2.9
通讯作者：
Hwa, JJ
中科院分区：
文献类型：
--
作者：
Gao, J;Ghibaudi, L;Hwa, JJ
当维持高脂肪饮食6个月，然后维持低脂饮食1个月时，Sprague-Dawley大鼠的一个子集发展为持续性肥胖，而来自同一大鼠队列的另一个子集在相同的饮食方案下保持精益。饮食诱导肥胖（DIO）大鼠能量摄入大于消耗，而饮食抵抗（DR）大鼠维持能量平衡。DIO大鼠的呼吸商增加，血浆瘦素、胰岛素和胆固醇水平升高。DIO大鼠下丘脑区NPY和AGRP mRNA表达升高，而MCH mRNA表达无明显变化。我们的数据表明，下丘脑中NPY和AGRP表达的增加可能有助于DIO大鼠持续性肥胖的发展。(C)2002 Elsevier Science B. V.保留所有权利。
A subset of Sprague-Dawley rats developed persistent obesity when maintained on a high-fat diet for 6 months followed by a low-fat diet for 1 month, while another subset from the same cohort of rats remained lean on the same diet regimens. The diet-induced obese (DIO) rats had higher energy intake than expenditure, while diet-resistant (DR) rats maintained energy balance. DIO rats also had an increased respiratory quotient and higher levels of plasma leptin, insulin and cholesterol. In the hypothalamic areas, DIO rats had elevated NPY and AGRP mRNA, but not MCH mRNA. Our data suggest that the increase in hypothalamic expression of NPY and AGRP may contribute to the development of persistent obesity in DIO rats. (C) 2002 Elsevier Science B.V. All rights reserved.