TOTAL SERUM TESTOSTERONE AND GONADOTROPINS IN WORKERS EXPOSED TO DIOXIN
TOTAL SERUM TESTOSTERONE AND GONADOTROPINS IN WORKERS EXPOSED TO DIOXIN
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DOI：
10.1093/oxfordjournals.aje.a116994
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发表时间：
1994-02-01
影响因子：
5
通讯作者：
HALPERIN, WE
中科院分区：
文献类型：
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作者：
EGELAND, GM;SWEENEY, MH;HALPERIN, WE
人类生殖内分泌数据可能是有关2，3，7，8-四氯二苯并对二恶英(二恶英)毒性的流行病学信息的重要来源。对来自新泽西州和密苏里州工厂的248名化学生产工人和231名参加1987年医学评估的非接触社区参照者的血清二恶英与血清总睾酮、黄体生成素和卵泡刺激素的相关性进行了研究。在线性回归分析中，当前血清二恶英与黄体生成素和卵泡刺激素呈显著正相关，与总睾酮呈显著负相关(p<；0.05)。这些趋势在Logistic回归分析中也很明显，在这些分析中，作者检查了高黄体生成素(>；28IU/升)、高卵泡刺激素(>；31IU/升)和低睾酮(>；31IU/升)的优势比。
Human reproductive endocrine data may be an important source of epidemiologic information in regard to the toxic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). The association of serum dioxin with total serum testosterone, luteinizing hormone, and follicle-stimulating hormone was examined in 248 chemical production workers from New Jersey and Missouri plants and 231 nonexposed neighborhood referents who participated in a medical evaluation in 1987. In linear regression analyses, current serum dioxin was positively and significantly related to luteinizing hormone and follicle-stimulating hormone and inversely related to total testosterone after adjustment for potential confounders (p < 0.05). These trends were also apparent in logistic regression analyses, in which the authors examined the odds ratios of high luteinizing hormone (>28 IU/liter), high follicle-stimulating hormone (>31 IU/liter), and low testosterone (