A mechanosensory system controls cell shape changes during mitosis
A mechanosensory system controls cell shape changes during mitosis
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DOI：
10.4161/cc.6.1.3674
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发表时间：
2007-01-01
期刊：
影响因子：
4.3
通讯作者：
Robinson, Douglas N.
中科院分区：
文献类型：
--
作者：
Effler, Janet C.;Iglesias, Pablo A.;Robinson, Douglas N.
基本的生命过程在很大程度上受到各种积极和消极反馈系统的控制。胞质分裂失败，最终导致非整倍性，被认为是哺乳动物肿瘤形成的早期步骤，对所有细胞都是有害的。此外，越来越多的癌症易感性突变包括许多基因，其蛋白质控制有丝分裂和/或胞质分裂。胞质分裂形状控制也是多细胞发育过程中模式形成和细胞类型特化的重要组成部分。固有的机械，我们假设，mechanosensing和机械反馈是胞质分裂形状调节的基础。使用机械扰动，我们确定了一个mechanosensory控制系统，监测胞质分裂过程中的形状进展。在这篇综述中，我们总结了这些发现及其对胞质分裂调控和理解支配形状控制的细胞骨架系统结构的影响。
Essential life processes are heavily controlled by a variety of positive and negative feedback systems. Cytokinesis failure, ultimately leading to aneuploidy, is appreciated as an early step in tumor formation in mammals and is deleterious for all cells. Further, the growing list of cancer predisposition mutations includes a number of genes whose proteins control mitosis and/or cytokinesis. Cytokinesis shape control is also an important part of pattern formation and cell-type specialization during multi-cellular development. Inherently mechanical, we hypothesized that mechanosensing and mechanical feedback are fundamental for cytokinesis shape regulation. Using mechanical perturbation, we identified a mechanosensory control system that monitors shape progression during cytokinesis. In this review, we summarize these findings and their implications for cytokinesis regulation and for understanding the cytoskeletal system architecture that governs shape control.