DNA RECOGNITION CODE OF TRANSCRIPTION FACTORS IN THE HELIX-TURN-HELIX, PROBE HELIX, HORMONE-RECEPTOR, AND ZINC-FINGER FAMILIES
DNA RECOGNITION CODE OF TRANSCRIPTION FACTORS IN THE HELIX-TURN-HELIX, PROBE HELIX, HORMONE-RECEPTOR, AND ZINC-FINGER FAMILIES
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DOI：
10.1073/pnas.91.26.12357
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发表时间：
1994-12-20
影响因子：
11.1
通讯作者：
YAGI, N
中科院分区：
文献类型：
--
作者：
SUZUKI, M;YAGI, N
我们之前报道过，在四个转录因子家族中，DNA识别规则可以描述为（i）化学规则，列出20个氨基酸残基和四个DNA碱基之间可能的配对，以及（ii）立体化学规则，描述接触的碱基和氨基酸位置。我们已将这些规则合并到计算机程序中并检查了规则的性质。至此，我们得出结论：DNA 识别规则简单、合乎逻辑且一致。这些规则足够具体，可以根据蛋白质序列预测 DNA 结合特征。
We have previously reported that in four transcription factor families the DNA-recognition rules can be described as (i) chemical rules, which list possible pairings between the 20 amino acid residues and the four DNA bases, and (ii) stereochemical rules, which describe the base and amino acid positions in contact. We have incorporated these rules into a computer program and examined the nature of the rules. Here we conclude that the DNA recognition rules are simple, logical, and consistent. The rules are specific enough to predict DNA-binding characteristics from a protein sequence.