EXPERIMENTAL INTESTINAL COLIFORM INFECTIONS IN MICE
EXPERIMENTAL INTESTINAL COLIFORM INFECTIONS IN MICE
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DOI：
10.1017/s0022172400039449
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发表时间：
1962-01-01
影响因子：
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通讯作者：
MUSHIN, R
中科院分区：
文献类型：
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作者：
ASHBURNER, F;MUSHIN, R
使用抗生素抑制正常肠道菌群并引入耐链霉素大肠菌群的技术用于小鼠感染研究。结果表明，大肠杆菌，无论是致病性粪便菌株还是正常粪便菌株，都倾向于定植于上肠道和下肠道区域。口服十个或更少的细胞剂量可能会产生慢性感染。即使初始剂量为 109 种细菌，感染也无症状。没有迹象表明致病性大肠菌群与正常大肠菌群竞争时具有生长优势。
A technique involving the suppression of normal intestinal flora with antibiotics, and the introduction of streptomycin-resistant coliforms was used for the study of infections in mice. It was shown that Escherichia coli, both the enteropathogenic and normal fecal strains, tend to colonize the upper intestinal tract as well as the lower region. An oral dose of ten or less cells could produce a chronic infection. Infections were asymptomatic even with an initial dose of 109 bacteria. There was no indication of growth advantages for enteropathogenic coliforms in competition with normal.