Eradication of Helicobacter pylori for prevention of ulcer recurrence after simple closure of perforated peptic ulcer: a meta-analysis of randomized controlled trials.
Eradication of Helicobacter pylori for prevention of ulcer recurrence after simple closure of perforated peptic ulcer: a meta-analysis of randomized controlled trials.
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DOI：
10.1016/j.jss.2012.10.046
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发表时间：
2013-06
期刊：
影响因子：
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通讯作者：
Chung-Shun Wong;C. Chia;Hung-Chia Lee;P. Wei;Hon-Ping Ma;S. Tsai;Chih‐Hsiung Wu;K. Tam
中科院分区：
文献类型：
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作者：
Chung-Shun Wong;C. Chia;Hung-Chia Lee;P. Wei;Hon-Ping Ma;S. Tsai;Chih‐Hsiung Wu;K. Tam
背景根除幽门螺杆菌已成为消化性溃疡标准治疗的一部分。然而，幽门螺杆菌根除在消化性溃疡穿孔中的作用仍存在争议。目前还不清楚是否根除细菌授予长期溃疡缓解后，简单的修补穿孔消化性ulcer.METHODSA系统回顾和荟萃分析的随机对照试验进行评估幽门螺杆菌根除预防溃疡复发后，简单的关闭穿孔消化性ulcer。评估这些影响的主要结果是术后溃疡的发生率;次要结果是幽门螺杆菌的消除率。幽门螺杆菌感染的高患病率发生在穿孔的消化性溃疡患者。根除幽门螺杆菌可显著降低术后8周（风险比2.97; 95%可信区间：1.06-8.29）和1年（风险比1.49; 95%可信区间：1.10-2.03）溃疡复发率。幽门螺杆菌的根除率显着高于治疗组比nontreatmentgroup. CONCLUSIONSERFERANCE治疗应提供给幽门螺杆菌感染的患者后，简单的关闭胃十二指肠溃疡穿孔。
BACKGROUNDEradication of Helicobacter pylori has become part of the standard therapy for peptic ulcer. However, the role of H pylori eradication in perforation of peptic ulcers remains controversial. It is unclear whether eradication of the bacterium confers prolonged ulcer remission after simple repair of perforated peptic ulcer.METHODSA systematic review and meta-analysis of randomized controlled trials was performed to evaluate the effects of H pylori eradication on prevention of ulcer recurrence after simple closure of perforated peptic ulcers. The primary outcome to evaluate these effects was the incidence of postoperative ulcers; the secondary outcome was the rate of H pylori elimination.RESULTSThe meta-analysis included five randomized controlled trials and 401 patients. A high prevalence of H pylori infection occurred in patients with perforated peptic ulcers. Eradication of H pylori significantly reduced the incidence of ulcer recurrence at 8 wk (risk ratio 2.97; 95% confidence interval: 1.06–8.29) and 1 y (risk ratio 1.49; 95% confidence interval: 1.10–2.03) postoperation. The rate of H pylori eradication was significantly higher in the treatment group than in the nontreatment group.CONCLUSIONSEradication therapy should be provided to patients with H pylori infection after simple closure of perforated gastroduodenal ulcers.