Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial
Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial
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DOI：
10.1016/s2213-8587(17)30327-3
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发表时间：
2017-12-01
影响因子：
44.5
通讯作者：
Kadowaki, Takashi
中科院分区：
文献类型：
--
作者：
Ueki, Kohjiro;Sasako, Takayoshi;Kadowaki, Takashi
背景有限的证据表明，多因素干预控制血糖、血压和血脂可降低2型糖尿病患者的大血管并发症和死亡率。然而，这些危险因素的安全和有效的治疗目标尚未确定为这样的interventions.Methods在这个多中心，开放标签，随机，平行组试验，在日本的81个临床站点进行，我们随机分配（1：1）2型糖尿病患者，年龄45-69岁，高血压，血脂异常，或两者兼而有之，HbA（1c）为6.9%（52.0 mmol/mol）或更高，接受常规治疗以控制血糖、血压和血脂（目标：HbA（1c）< 6.9% [52.0 mmol/mol]，血压
Background Limited evidence suggests that multifactorial interventions for control of glucose, blood pressure, and lipids reduce macrovascular complications and mortality in patients with type 2 diabetes. However, safe and effective treatment targets for these risk factors have not been determined for such interventions.Methods In this multicentre, open-label, randomised, parallel-group trial, undertaken at 81 clinical sites in Japan, we randomly assigned (1:1) patients with type 2 diabetes aged 45-69 years with hypertension, dyslipidaemia, or both, and an HbA(1c) of 6.9% (52.0 mmol/mol) or higher, to receive conventional therapy for glucose, blood pressure, and lipid control (targets: HbA(1c) < 6.9% [52.0 mmol/mol], blood pressure