The pregnancy rates with intrauterine insemination (IUI) in superovulated cycles employing different protocols (clomiphen citrate (CC), human menopausal gonadotropin (HMG) and HMG+CC) and in natural ovulatory cycle.
The pregnancy rates with intrauterine insemination (IUI) in superovulated cycles employing different protocols (clomiphen citrate (CC), human menopausal gonadotropin (HMG) and HMG+CC) and in natural ovulatory cycle.
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发表时间：
2004-10
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通讯作者：
Mahani Im;M. Afnan
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作者：
Mahani Im;M. Afnan
目的比较不同促排卵方案对不孕夫妇进行IUI的效果。方法回顾性分析209对不明原因、男性因素、子宫内膜异位症、输卵管疾病、排卵障碍、多因素不孕的不孕夫妇，采用不同的促排卵方案：CC 50-100 mg，第2-6天; CC 50 mg，第2 - 6天+HMG 2amp，第5、7、9、11天;精子贮存者采用自然排卵周期+ IUI。在注射HCG后36-40小时进行了441个连续周期的IUI。资料分析采用Student t检验和Mann-Whitney检验。显著性定义为P<0.005。结果发生31例妊娠（每个周期7%，每个患者15%）。8例患者接受了37个周期的自然排卵IUI，发生1例妊娠（每个周期妊娠率为2%，每个患者为12%）。27例接受41个周期IUI的患者中，CC的结果是2例妊娠（4%/周期，7%/患者）。在129例接受283个周期CC+HMG IUI的患者中，发生21例妊娠（每个周期7%，每例患者16%）。在35例接受80个周期HMG IUI的患者中，发生8例妊娠（每个周期9%，每例患者23%）。结论诱导排卵方法的选择对IUI的成功有重要影响。与自然排卵周期相比，采用诱导排卵的方法进行IUI的效果更好。HMG+IUI的妊娠率高于CC+IUI、CC+HMG+IUI和自然排卵周期+IUI。
OBJECTIVE To compare the result of IUI in infertile couples with different protocols of induction ovulation. METHODS In a retrospective study, 209 infertile couples with different diagnosis (unexplained, male factor, endometriosis, tubal disease, ovulatory dysfunction and multifactorial infertility) were subjected to different protocol of induction ovulation: 50-100 mg CC in day 2-6, 50 mg CC in day 2-6 + 2 amp HMG in day 5, 7, 9, 11, and 2 amp HMG per day. Natural ovulatory cycle + IUI was used for sperm stored patients. 441 consecutive cycles of IUI was performed 36-40 hours after HCG injection. The data were analysed with student T-test and Mann-Whitney test. The significance was defined as P<0.005. RESULTS Thirty one pregnancies (7% per cycle, 15% per patient) occurred. One pregnancy occurred (pregnancy per cycle was 2% and per patient was 12%) in 8 patients undergoing 37 cycles of IUI with natural ovulation. The result with CC in 27 patients undergoing 41 cycles IUI was 2 pregnancies (4% per cycle, 7% per patient). In 129 patients receiving 283 cycles of IUI with CC+HMG 21 pregnancies occurred (7% per cycle, 16% per patient). In 35 patients receiving 80 cycles of IUI with HMG 8 pregnancies occurred (9% per cycle, 23% per patient). CONCLUSION The method chosen for ovulation induction had a critical bearing on the success of IUI. The result of IUI will be better by using induction ovulation compared to natural ovulatory cycle. In our programme the combined use of HMG+IUI yielded a higher rate of pregnancy rate compared with CC+IUI, CC+HMG+IUI and natural ovulatory cycle+IUI.