Anti-tumor promoting effect of glycosides from Prunus persica seeds
Anti-tumor promoting effect of glycosides from Prunus persica seeds
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DOI：
10.1248/bpb.26.271
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发表时间：
2003-02-01
影响因子：
2
通讯作者：
Yoshida, T
中科院分区：
文献类型：
--
作者：
Fukuda, T;Ito, H;Yoshida, T
从桃仁种子（Persicae Semen；Tounin）中分离出四种次要成分，以及主要的氰苷、苦杏仁甙和苦杏仁苷，并被表征为扁桃酸苷（β-龙胆二糖苷和β-D-葡萄糖苷）和苯甲醇糖苷（β-龙胆二糖苷和β-D-葡萄糖苷）。在体外和体内测定中检查了这些化合物的抗肿瘤促进活性。所有化合物均显着抑制肿瘤启动子诱导的 Epstein-Barr 病毒早期抗原激活。此外，它们还能延迟小鼠皮肤的两阶段致癌作用，其效力与绿茶中的 (-)-表没食子儿茶素没食子酸酯相当。构效关系表明，苄基上有取代基。具有糖苷键的位置以增强效力的顺序影响体外和体内活性，CN
Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting activity of these compounds was examined in both in vitro and in vivo assays. All of the compounds significantly inhibited the Epstein-Barr virus early antigen activation induced by tumor promoter. In addition, they produced a delay of two-stage carcinogenesis on mouse skin that was comparable in potency to (-)-epigallo-catechin gallate from green tea. Structure-activity relationships indicated that a substituent at the benzylic. position with glycosidic linkage affected the in vitro and in vivo activities with an order of enhancing potency, CN