Neighborhood disadvantage and biological aging biomarkers among breast cancer patients.
Neighborhood disadvantage and biological aging biomarkers among breast cancer patients.
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乳腺癌患者的邻里劣势和生物老化生物标志物。
DOI：
10.1038/s41598-022-15260-0
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发表时间：
2022-06-30
影响因子：
4.6
通讯作者：
Zhao, Hua
中科院分区：
文献类型：
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作者：
Shen, Jie;Fuemmeler, Bernard F;Sheppard, Vanessa B;Bear, Harry D;Song, Renduo;Chow, Wong-Ho;Zhao, Hua
生活在弱势社区与乳腺癌患者的不良临床结果有关，但潜在的途径尚不清楚。有限的证据表明，加速的生物衰老可能起着重要作用。在这项研究中，我们使用了906名在M.D. Anderson新诊断的乳腺癌女性的子样本，研究了选定的生物衰老标志物（例如，适应负荷、端粒长度和整体DNA甲基化）的水平是否受到社区不利因素的影响。利用区域剥夺指数（Area Deprivation Index）来确定邻域劣势。根据国家水平的中位数ADI，将研究人群分为低ADI组和高ADI组。总体而言，与低ADI组相比，高ADI组的乳腺癌患者更可能是年轻人和非西班牙裔黑人（P < 0.001）。她们也更有可能患有更高级别和低分化的乳腺肿瘤（P分别为0.029和0.019）。对于与标记物的关系，与低ADI组相比，高ADI组具有更高的适应负荷中位数水平（P = 0.046）和更低的总体DNA甲基化中位数水平（P < 0.001）。与对照组相比，高ADI组患者适应负荷增加的可能性高20%，整体DNA甲基化水平增加的可能性低51%。总之，我们观察到乳腺癌患者的适应负荷水平和整体DNA甲基化水平受到社区劣势的影响。
Living in a disadvantaged neighborhood is associated with adverse clinical outcomes among breast cancer patients, but the underlying pathway is still unclear. Limited evidence has suggested that accelerated biological aging may play an important role. In this study, using a sub-sample of 906 women with newly diagnosed breast cancer at M.D. Anderson, we examined whether levels of selected markers of biological aging (e.g., allostatic load, telomere length, and global DNA methylation) were affected by neighborhood disadvantage. The Area Deprivation Index was used to determine the neighborhood disadvantage. Based on the median ADI at the national level, the study population was divided into low and high ADI groups. Overall, breast cancer patients from the high ADI group were more likely to be younger and non-Hispanic Black than those from the low ADI group (P < 0.001, respectively). They were also more likely to have higher grade and poorly differentiated breast tumors (P = 0.029 and 0.019, respectively). For the relationship with markers, compared to the low ADI group, high ADI group had higher median levels of allostatic load (P = 0.046) and lower median levels of global DNA methylation (P < 0.001). Compared to their counterparts, those from the high ADI group were 20% more likely to have increased allostatic load and 51% less likely to have increased levels of global DNA methylation. In summary, we observed that levels of allostatic load and global DNA methylation are influenced by neighborhood disadvantage among breast cancer patients.