Inorganic arsenic in drinking water and bladder cancer: a meta-analysis for dose-response assessment.
Inorganic arsenic in drinking water and bladder cancer: a meta-analysis for dose-response assessment.
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DOI：
10.3390/ijerph2006030039
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发表时间：
2006-12-01
影响因子：
--
通讯作者：
Crawford-Brown, Douglas J
中科院分区：
文献类型：
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作者：
Chu, Huei-An;Crawford-Brown, Douglas J
大多数砷癌症风险评估仅基于流行病学研究，以描述砷相关癌症的剂量反应关系并进行风险计算。然而，目前的流行病学证据不一致，并且充满砷暴露的不确定性，无法提供可靠的估计。这使得很难从个别研究中得出关于剂量反应关系的形状和斜率的明确结论。荟萃分析是一种结合研究结果的统计方法，为获得改善的剂量反应关系提供了更多机会。本研究通过结合来自不同地区的七项流行病学研究，对砷研究进行荟萃分析，得出砷摄入量与膀胱癌超标概率之间的整体剂量反应关系。固定效应和随机效应模型均用于计算线性逻辑回归模型的平均系数。还进行了同质性测试。这项研究的最终产品是在砷的经验观察范围内的聚合剂量反应模型。考虑到最新的砷 MCL（最大污染物水平，即 10μg/L），该 MCL 的相关膀胱癌风险（终生超标概率）为 2.29 x 10-5。
Most arsenic cancer risk assessments have been based solely on epidemiological studies to characterize the dose-response relationship for arsenic-associated cancer and to perform risk calculations. However, current epidemiological evidence is too inconsistent and fraught with uncertainty regarding arsenic exposure to provide reliable estimates. This makes it hard to draw a firm conclusion about the shape and slope of the dose-response relationship from individual studies. Meta-analysis is a statistical approach to combining results across studies and offers expanded opportunities for obtaining an improved dose-response relationship. In this study, a meta-analysis of arsenic studies was conducted by combining seven epidemiological studies from different regions to get an overall dose-response relationship between the amount of arsenic intake and the excess probability of bladder cancer. Both the fixed-effect and random-effect models were used to calculate the averaged coefficient of the linear-logistic regression model. A homogeneity test was also conducted. The final product of this research is an aggregated dose-response model in the range of empirical observation of arsenic. Considering the most recent arsenic MCL (maximum contaminant level, i.e. 10microg/L), the associated bladder cancer risk (lifetime excess probability) at this MCL is 2.29 x 10-5.