GENETIC-ANALYSIS OF THE HOMEOTIC GENE-COMPLEX (HOM-C) IN THE BEETLE TRIBOLIUM-CASTANEUM
GENETIC-ANALYSIS OF THE HOMEOTIC GENE-COMPLEX (HOM-C) IN THE BEETLE TRIBOLIUM-CASTANEUM
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DOI：
10.1016/0012-1606(89)90311-4
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发表时间：
1989-05-01
影响因子：
2.7
通讯作者：
DENELL, RE
中科院分区：
文献类型：
--
作者：
BEEMAN, RW;STUART, JJ;DENELL, RE
我们的实验室进行了遗传和分子研究的同源异型基因复合体（HOM-C）的甲虫赤拟谷盗，本文讨论了我们的遗传分析的结果。我们在这里描述的成人表型和互补行为超过50个新的突变。这些同源异型表型中的许多类似于黑腹果蝇的表型，但很少有精确地平行于在这种果蝇中看到的节段转换。对影响头部和胸部的假定功能丧失突变的分析表明，上颌足和头胸基因最接近于果蝇的长鼻足和性梳减少。在腹部，Abdominal的假定的功能丧失等位基因影响与果蝇的Abdominal-A和Abdominal-B基因的组合相对应的域。与果蝇的情况相反，拟谷盗属的腹部功能丧失变体导致A3-A5 a的向前转化，但A5 p-A7的向后转化。的发展策略的差异，在拟谷盗与果蝇进化的影响进行了讨论。
Our laboratories have undertaken both genetic and molecular studies of the homeotic gene complex (HOM-C) of the beetle Tribolium castaneum, and this paper discusses results from our genetic analyses. We describe here the adult phenotypes and complementation behavior of over 50 new mutations. Many of these homeotic phenotypes resemble those of Drosophila melanogaster, but few precisely parallel the segmental transformations seen in this fly. Analysis of putative loss-of-function mutations affecting the head and thorax suggests that the maxillopedia and Cephalothorax genes most closely resemble proboscipedia and Sex combs reduced of Drosophila. In the abdomen, putative loss-of-function alleles of Abdominal affect a domain corresponding to those of the combined abdominal-A and Abdominal-B genes of Drosophila. In contrast to the situation in flies, Abdominal loss-of-function variants in Tribolium cause anteriorward transformations in A3-A5a, but posteriorward transformations in A5p-A7. The implications of the differences in developmental strategies evolved in Tribolium vs Drosophila are discussed.